human CD34 Mouse mAb (一抗) | Bioss

bsm-30097M

流式抗体

human CD34 Mouse mAb

小鼠抗人CD34单克隆抗体

CD34_HUMAN; CD34;

Mouse

KLH conjugated synthetic peptide derived from human CD34

Mouse IgG1

Liquid

affinity purified by Protein G

Monoclonal

4H11

39 kDa

105-120 kDa

1mg/ml

0.01M TBS (pH7.4).

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

造血干细胞标志物
内皮标志物
肿瘤生物标志物

细胞表面的唾液粘蛋白。

The highly glycosylated 75-120 kD antigen CD34 is possibly an adhesion molecule with a putative role in early hematopoiesis by mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells. It could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components. CD34 is thought to have a role in presenting carbohydrate ligands to selectins. The intracellular chain of the CD34 antigen is a site of phosphorylation by activated protein kinase C, suggesting a putative role in signal transduction. Two isoforms of CD34 have been reported to be generated by alternative splicing. CD34 is highly expressed on hematopoietic progenitors, as well as on endothelial cells, brain, and testis. Staining for CD34 has been used to measure angiogenesis, which reportedly predicts tumor recurrence.