混合系列蛋白激酶样结构域重组兔单抗

bsm-52256R

重组兔单抗

MLKL Recombinant Rabbit mAb

混合系列蛋白激酶样结构域重组兔单抗

hMLKL; 9130019I15Rik; MLKL_HUMAN; MLKL; MLKL_MOUSE;

Rabbit

A synthesized peptide derived from human MLKL: 350-471

IgG

Liquid

affinity purified by Protein A

Recombinant

3G4

54 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015].