KAT2B Rabbit pAb (一抗) | Bioss
货号：bs-5130R
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概述
产品编号
bs-5130R
产品类型
宠物抗体、农牧业/家禽抗体
英文名称
KAT2B Rabbit pAb
中文名称
组蛋白乙酰转移酶PCAF抗体
英文别名
CAF; P/CAF; PCAF; A930006P13Rik; KAT2B_HUMAN; KAT2B; Histone acetyltransferase PCAF (Histone acetylase PCAF); Lysine acetyltransferase 2B; P300/CBP-associated factor (P/CAF); Spermidine acetyltransferase KAT2B; 2.3.1.48; KAT2B_MOUSE;
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human KAT2B: 451-550/832
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
92 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
Cell Biology > Cell Cycle > Cell Cycle Inhibitors
Epigenetics and Nuclear Signaling > Bromodomains
Epigenetics and Nuclear Signaling > Chromatin Modifying Enzymes > Acetylation
Epigenetics and Nuclear Signaling > Chromatin Modifying Enzymes > Acetylation > HAT
Epigenetics and Nuclear Signaling > Transcription > Other factors
Microbiology > Interspecies Interaction > Host Virus Interaction
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| IHC-P | Human, Mouse, Rat | Pig, Chicken, Dog, Horse | 1:100-500 |
| IHC-F | Human, Mouse, Rat | Pig, Chicken, Dog, Horse | 1:100-500 |
| IF | Human, Mouse, Rat | Pig, Chicken, Dog, Horse | 1:100-500 |
交叉反应
交叉反应: Human, Mouse, Rat (predicted: Pig, Chicken, Dog, Horse)
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靶标
基因名
KAT2B
蛋白名
Histone acetyltransferase KAT2B
亚基
Interacts with SIRT1. Interacts (unsumoylated form) with NR2C1; the interaction promotes transactivation activity (By similarity). Interacts with EP300, CREBBP and DDX17. Interacts with NCOA1 and NCOA3. Component of a large chromatin remodeling complex, at least composed of MYSM1, KAT2B/PCAF, RBM10 and KIF11/TRIP5. Interacts with NR2C2 (hypophosphorylated and unsumoylated form); the interaction promotes the transactivation activity of NR2C2. Binds to HTLV-1 Tax. Interacts with and acetylates HIV-1 Tat. Interacts with KLF1; the interaction does not acetylate KLF1 and there is no enhancement of its transactivational activity. Interacts with NFE4. Interacts with MECOM. Interacts with E2F1; the interaction acetylates E2F1 augmenting its DNA-binding and transcriptional activity.
亚细胞定位
Nucleus.
组织特异性
Ubiquitously expressed but most abundant in heart and skeletal muscle.
相似性
Belongs to the GCN5 family.
Contains 1 bromo domain.
Contains 1 N-acetyltransferase domain.
Contains 1 bromo domain.
Contains 1 N-acetyltransferase domain.
功能
Functions as a histone acetyltransferase (HAT) to promote transcriptional activation. Has significant histone acetyltransferase activity with core histones (H3 and H4), and also with nucleosome core particles. Inhibits cell-cycle progression and counteracts the mitogenic activity of the adenoviral oncoprotein E1A. In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes.
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