beta 2 Microglobulin Rabbit pAb (一抗) | Bioss
货号：bs-41176R
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概述
产品编号
bs-41176R
英文名称
beta 2 Microglobulin Rabbit pAb
中文名称
β2-微球蛋白抗体
英文别名
AMYLD6; IMD43; MHC1D4; Ly-m11; beta2-m; beta2m; B2MG_HUMAN; B2M; B2MG_MOUSE; B2MG_RAT; beta-2-microglobulin
抗体来源
Rabbit
免疫原
Recombinant human Beta-2-Microglobulin protein
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
13/27 kDa
检测分子量
11 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
小鼠抗人β2微球蛋白在中枢神经系统感染、肿瘤及全身性自身免疫性疾病患者脑脊液中，会出现β2MG蛋白不同程度的增高。
背景资料
This gene encodes a serum protein found in association with the major histocompatibility complex (MHC) class I heavy chain on the surface of nearly all nucleated cells. The protein has a predominantly beta-pleated sheet structure that can form amyloid fibrils in some pathological conditions. A mutation in this gene has been shown to result in hypercatabolic hypoproteinemia.[provided by RefSeq, Sep 2009].
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | 1:500-2000 |
交叉反应
交叉反应: Human
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靶标
基因名
B2M
蛋白名
beta-2-microglobulin
亚基
Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis.
亚细胞定位
Secreted. Note=Detected in serum and urine.
翻译后修饰
Glycation of Ile-21 is observed in long-term hemodialysis patients.
疾病
Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation.
Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.
Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis.
相似性
Belongs to the beta-2-microglobulin family.
Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
Contains 1 Ig-like C1-type (immunoglobulin-like) domain.
功能
Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system.
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