LOR/Loricrin Rabbit pAb (一抗) - IHC-P,IHC-F,IF | Bioss
货号：bs-18340R
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概述
产品编号
bs-18340R
产品类型
农牧业/家禽抗体
英文名称
LOR/Loricrin Rabbit pAb
中文名称
兜甲蛋白抗体
英文别名
LOR; RGD1559993; LORI_HUMAN; LORICRIN; LRN; LORI_MOUSE;
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human LOR/Loricrin: 251-312/312
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
26 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
This gene encodes loricrin, a major protein component of the cornified cell envelope found in terminally differentiated epidermal cells. Mutations in this gene are associated with Vohwinkel's syndrome and progressive symmetric erythrokeratoderma, both inherited skin diseases. [provided by RefSeq, Jul 2008]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| IHC-P | Human | Mouse, Rat, Horse | 1:100-500 |
| IHC-F | Human | Mouse, Rat, Horse | 1:100-500 |
| IF | Human | Mouse, Rat, Horse | 1:100-500 |
交叉反应
交叉反应: Human (predicted: Mouse, Rat, Horse)
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靶标
基因名
LORICRIN
蛋白名
Loricrin
亚细胞定位
Cytoplasm. Nucleus；nucleoplasm.
翻译后修饰
Substrate of transglutaminases. Some glutamines and lysines are cross-linked to other loricrin molecules and to SPRRs proteins.
Contains inter- or intramolecular disulfide-bonds.
Contains inter- or intramolecular disulfide-bonds.
疾病
Defects in LOR are a cause of progressive symmetric erythrokeratodermia (PSEK) [MIM:133200]. Erythrokeratodermas are a group of disorders characterized by widespread erythematous plaques, either stationary or migratory, associated with features that include palmoplantar keratoderma. PSEK is characterized by erythematous and hyperkeratotic plaques.
Defects in LOR are the cause of Vohwinkel syndrome with ichthyosis (VSI) [MIM:604117]; also known as loricrin keratoderma (LK) or mutilating keratoderma with ichthyosis. VSI is an ichthyotic variant of Vohwinkel syndrome (VS) characterized by progressive symmetric erythrokeratoderma or congenital ichthyosiform erythroderma born as a collodion baby. Common clinical features include hyperkeratosis of the palms and soles with digital constriction.
Defects in LOR are the cause of Vohwinkel syndrome with ichthyosis (VSI) [MIM:604117]; also known as loricrin keratoderma (LK) or mutilating keratoderma with ichthyosis. VSI is an ichthyotic variant of Vohwinkel syndrome (VS) characterized by progressive symmetric erythrokeratoderma or congenital ichthyosiform erythroderma born as a collodion baby. Common clinical features include hyperkeratosis of the palms and soles with digital constriction.
功能
Major keratinocyte cell envelope protein.
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