PRDX2 Rabbit pAb (一抗) - WB,IHC-P,IHC-F,IF | Bioss
货号：bs-8300R
产品详情
相关标记
相关产品
相关文献
常见问题
概述
产品编号
bs-8300R
产品类型
宠物抗体、农牧业/家禽抗体
英文名称
PRDX2 Rabbit pAb
中文名称
过氧化物酶-2抗体
英文别名
HEL-S-2a; NKEF-B; NKEFB; PRP; PRX2; PRXII; PTX1; TDPX1; TPX1; TSA; Band-8; TDX1; TPx; TPx-B; TR; Torin; PRDX2_BOVIN; PRDX2; Thioredoxin-dependent peroxiredoxin 2; 1.11.1.24; PRDX2_HUMAN; Natural killer cell-enhancing factor B (NKEF-B); Thiol-specific antioxidant protein (TSA); Thioredoxin peroxidase 1; Thioredoxin-dependent peroxide reductase 1; PRDX2_MOUSE; PRDX2_RAT;
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human Peroxiredoxin-2
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
22 kDa
检测分子量
22 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
Cancer > Cancer Metabolism > Cellular metabolic process
Cell Biology > Other Antibodies > Oxidative Stress
Metabolism > Pathways and Processes > Redox metabolism > Oxidative stress
Metabolism > Types of disease > Cancer
Metabolism > Types of disease > Neurodegenerative disease
Neuroscience > Neurology process > Neurodegenerative disease > Alzheimer's disease
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
巯基特异性过氧化物酶，分别催化过氧化氢和有机过氧化氢还原为水和醇。作为过氧化氢介导的信号事件的传感器，在细胞对氧化应激的保护中发挥作用。可能通过调节细胞内过氧化氢浓度参与生长因子和肿瘤坏死因子α的信号级联。
背景资料
This gene encodes a member of the peroxiredoxin family of antioxidant enzymes, which reduce hydrogen peroxide and alkyl hydroperoxides. The encoded protein plays an antioxidant protective role in cells, and it may contribute to the antiviral activity of CD8(+) T-cells. The crystal structure of this protein has been resolved to 2.7 angstroms. This protein prevents hemolytic anemia from oxidative stress by stabilizing hemoglobin, thus making this gene a therapeutic target for patients with hemolytic anemia. This protein may have a proliferative effect and play a role in cancer development or progression. Related pseudogenes have been identified on chromosomes 5, 6, 10 and 13. [provided by RefSeq, Mar 2013]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse, Rat | 1:500-2000 | |
| IHC-P | Human, Mouse, Rat | 1:100-500 | |
| IHC-F | Human, Mouse, Rat | 1:100-500 | |
| IF | Human, Mouse, Rat | 1:100-500 |
交叉反应
交叉反应: Human, Mouse, Rat
相关产品
暂无相关产品
靶标
基因名
PRDX2
蛋白名
Peroxiredoxin-2
亚基
Homodimer; disulfide-linked, upon oxidation. May be found as a toroid-shaped decamer composed of 5 dimers, depending on pH and calcium concentration. Interacts with TIPIN.
亚细胞定位
Cytoplasm.
相似性
Belongs to the AhpC/TSA family.
Contains 1 thioredoxin domain.
Contains 1 thioredoxin domain.
功能
Involved in redox regulation of the cell. Reduces peroxides with reducing equivalents provided through the thioredoxin system. It is not able to receive electrons from glutaredoxin. May play an important role in eliminating peroxides generated during metabolism. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2).
同靶标产品
相关文献
提示: 发表研究结果有使用 bs-8300R 时请让我们知道，以便我们可以引用参考文章。作为回馈，资料提供者将获得我们送上的小礼品。