Hsc70 Rabbit pAb (一抗) - IHC-P,IHC-F,IF,Flow-Cyt,ICC/IF | Bioss
货号：bs-5117R
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概述
产品编号
bs-5117R
产品类型
农牧业/家禽抗体
英文名称
Hsc70 Rabbit pAb
中文名称
热休克蛋白71抗体
英文别名
HEL-33; HEL-S-72p; HSC54; HSC70; HSC71; HSP71; HSP73; HSPA10; LAP-1; LAP1; NIP71; 2410008N15Rik; Hsc73; HSP7C_HUMAN; HSPA8; Heat shock 70 kDa protein 8; Heat shock protein family A member 8; Lipopolysaccharide-associated protein 1 (LAP-1 | LPS-associated protein 1); 3.6.4.10; HSP7C_MOUSE; HSP7C_RAT;
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human HSP71: 501-600/646
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
71 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
This gene encodes a member of the heat shock protein 70 family, which contains both heat-inducible and constitutively expressed members. This protein belongs to the latter group, which are also referred to as heat-shock cognate proteins. It functions as a chaperone, and binds to nascent polypeptides to facilitate correct folding. It also functions as an ATPase in the disassembly of clathrin-coated vesicles during transport of membrane components through the cell. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| IHC-P | Mouse, Rat | Human, Rabbit, Pig, Cow, Chicken | 1:100-500 |
| IHC-F | Mouse, Rat | Human, Rabbit, Pig, Cow, Chicken | 1:100-500 |
| IF | Mouse, Rat | Human, Rabbit, Pig, Cow, Chicken | 1:100-500 |
| Flow-Cyt | Human | Mouse, Rat, Rabbit, Pig, Cow, Chicken | 1ug/test |
| ICC/IF | Mouse | Human, Rat, Rabbit, Pig, Cow, Chicken | 1:100-500 |
交叉反应
交叉反应: Human, Mouse, Rat (predicted: Rabbit, Pig, Cow, Chicken)
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靶标
基因名
HSPA8
蛋白名
Heat shock cognate 71 kDa protein
亚基
Interacts with HSPH1/HSP105. Interacts with IRAK1BP1 (By similarity). Identified in a mRNP granule complex, at least composed of ACTB, ACTN4, DHX9, ERG, HNRNPA1, HNRNPA2B1, HNRNPAB, HNRNPD, HNRNPL, HNRNPR, HNRNPU, HSPA1, HSPA8, IGF2BP1, ILF2, ILF3, NCBP1, NCL, PABPC1, PABPC4, PABPN1, RPLP0, RPS3, RPS3A, RPS4X, RPS8, RPS9, SYNCRIP, TROVE2, YBX1 and untranslated mRNAs. Interacts with PACRG and TSC2. Interacts with BAG1. Interacts with SV40 VP1. Interacts with DNAJC7 (By similarity). Interacts with HERC5. Interacts with CITED1 (via N-terminus); the interaction suppresses the association of CITED1 to p300/CBP and Smad-mediated transcription transactivation.
亚细胞定位
Cytoplasm. Melanosome.
组织特异性
Ubiquitous.
翻译后修饰
Phosphorylated upon DNA damage, probably by ATM or ATR.
ISGylated.
相似性
Belongs to the heat shock protein 70 family.
功能
Acts as a repressor of transcriptional activation. Inhibits the transcriptional coactivator activity of CITED1 on Smad-mediated transcription. Chaperone. Isoform 2 may function as an endogenous inhibitory regulator of HSC70 by competing the co-chaperones.
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