NEUROD1 Recombinant Rabbit mAb (一抗) | Bioss
Rrmab?兔单抗
货号：bsm-52948R
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概述
产品编号
bsm-52948R
产品类型
重组兔单抗
英文名称
NEUROD1 Recombinant Rabbit mAb
中文名称
神经细胞分化因子1重组兔单抗
英文别名
BETA2; BHF-1; MODY6; NEUROD; T2D; bHLHa3; Nd1; NDF1_HUMAN; NEUROD1; Class A basic helix-loop-helix protein 3 (bHLHa3); NDF1_MOUSE; Beta-cell E-box transcriptional activator 2 (Beta2); NDF1_RAT; Basic helix-loop-helix factor 1 (BHF-1); neuronal differentiation 1; neurogenic differentiation 1; beta-cell E-box transactivator 2; neurogenic helix-loop-helix protein NEUROD
抗体来源
Rabbit
免疫原
A synthesized peptide derived from human NeuroD: 1-40/356
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
1C9
理论分子量
40 kDa
检测分子量
45 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
Cardiovascular > Atherosclerosis > Diabetes associated
Epigenetics and Nuclear Signaling > Transcription > Domain Families > HLH / Leucine Zipper > HLH
Metabolism > Types of disease > Diabetes
Metabolism > Types of disease > Heart disease
Neuroscience > Cell Type Marker > Neural Stem Cell marker
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
神经生物学相关蛋白(Neurobiology)
背景资料
This gene encodes a member of the NeuroD family of basic helix-loop-helix (bHLH) transcription factors. The protein forms heterodimers with other bHLH proteins and activates transcription of genes that contain a specific DNA sequence known as the E-box. It regulates expression of the insulin gene, and mutations in this gene result in type II diabetes mellitus. [provided by RefSeq, Jul 2008]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | 1:500-2000 |
交叉反应
交叉反应: Human, Rat
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靶标
基因名
NEUROD1
蛋白名
Neurogenic differentiation factor 1
亚基
Interacts (via helix-loop-helix motif domain) with EP300(via C-terminus) (By similarity). Heterodimer with TCF3/E47; theheterodimer is inhibited in presence of ID2, but not NR0B2, toE-box element. Efficient DNA-binding requires dimerization withanother bHLH protein. Interacts with RREB1. Interacts with EP300;the interaction is inhibited by NR0B2. Interacts with TCF3; theinteraction is inhibited by ID2.
亚细胞定位
Cytoplasm. Nucleus.
翻译后修饰
Phosphorylated. In islet cells, phosphorylated on Ser-274 upon glucose stimulation; which may be required for nuclear localization. In activated neurons, phosphorylated on Ser-335; which promotes dendritic growth.
疾病
Defects in NEUROD1 are the cause of maturity-onset diabetes of the young type 6 (MODY6) [MIM:606394]. MODY is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.
相似性
Contains 1 basic helix-loop-helix (bHLH) domain.
功能
Differentiation factor required for dendrite morphogenesis and maintenance in the cerebellar cortex. Transcriptional activator. Binds to the insulin gene E-box.
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