TEF4 Rabbit pAb (一抗) | Bioss
货号：bs-8212R
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概述
产品编号
bs-8212R
产品类型
宠物抗体、农牧业/家禽抗体
英文名称
TEF4 Rabbit pAb
中文名称
转录增强因子TEF4抗体
英文别名
ETF; TEAD-2; TEF-4; TEF4; ETEF-1; Etdf; TEAD2_HUMAN; TEAD2; TEA domain family member 2 (TEAD-2); TEAD2_MOUSE; Embryonic TEA domain-containing factor (ETF); TEA domain transcription factor 2; TEA domain family member 2
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human TEA domain family member 2: 235-340/447
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
49 kDa
检测分子量
49 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
TEF-4 is strongly coexpressed with TEF-1 in mouse mitotic neuroblasts and is also detected in the gut and the nephrogenic region of the kidney. TEF-4 associates with the powerful transcriptional coactivator YAP65 to mediate mitogenic signals. In addition, TEF-4 promotes the activation of the CTP:phosphocholine cytidylyltransferase (CCT) alpha protein, which is the rate-limiting enzyme of phosphatidylcholine biosynthesis, by enhancing the transcriptional activity of Ets-1.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Mouse, Rat | Human, Rabbit, Cow, Dog, Horse | 1:500-2000 |
| IHC-P | Mouse | Human, Rat, Rabbit, Cow, Dog, Horse | 1:100-500 |
| IHC-F | Mouse | Human, Rat, Rabbit, Cow, Dog, Horse | 1:100-500 |
| IF | Mouse | Human, Rat, Rabbit, Cow, Dog, Horse | 1:100-500 |
交叉反应
交叉反应: Mouse, Rat (predicted: Human, Rabbit, Cow, Dog, Horse)
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靶标
基因名
TEAD2
蛋白名
Transcriptional enhancer factor TEF-4
亚基
Interacts with YAP1 and WWTR1/TAZ.
亚细胞定位
Nucleus.
相似性
Contains 1 TEA DNA-binding domain.
功能
Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Acts by mediating gene expression of YAP1 and WWTR1/TAZ, thereby regulating cell proliferation, migration and epithelial mesenchymal transition (EMT) induction. Binds to the SPH and GT-IIC 'enhansons' (5'-GTGGAATGT-3'). May be involved in the gene regulation of neural development. Binds to the M-CAT motif.
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