This gene encodes a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Tetraspanins are cell surface glycoproteins with four transmembrane domains that form multimeric complexes with other cell surface proteins. The encoded protein functions in many cellular processes including differentiation, adhesion, and signal transduction, and expression of this gene plays a critical role in the suppression of cancer cell motility and metastasis. [provided by RefSeq, Jan 2011]
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
WB
Mouse, Rat
Human, Rabbit, Pig, Sheep, Cow, Dog
1:500-2000
Flow-Cyt
Human, Mouse, Rat
Rabbit, Pig, Sheep, Cow, Dog
1μg/Test
交叉反应
交叉反应: Human, Mouse, Rat (predicted: Rabbit, Pig, Sheep, Cow, Dog)
相关产品
暂无相关产品
靶标
基因名
CD9
蛋白名
CD9 antigen
亚基
Forms both disulfide-linked homodimers and higher homooligomers as well as heterooligomers with other members of the tetraspanin family. Associates with CR2/CD21 and with PTGFRN/CD9P1. Interacts directly with IGSF8.
亚细胞定位
Membrane; Multi-pass membrane protein.
组织特异性
Expressed by a variety of hematopoietic and epithelial cells.
翻译后修饰
Protein exists in three forms with molecular masses between 22 and 27 kDa, and is known to carry covalently linked fatty acids.
相似性
Belongs to the tetraspanin (TM4SF) family.
功能
Involved in platelet activation and aggregation. Regulates paranodal junction formation. Involved in cell adhesion, cell motility and tumor metastasis. Required for sperm-egg fusion.