phospho-Cyclin C (Ser275) Rabbit pAb (一抗) - WB,IHC-P,IHC-F,IF | Bioss
货号：bs-14136R
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概述
产品编号
bs-14136R
产品类型
磷酸化抗体、宠物抗体、农牧业/家禽抗体
英文名称
phospho-Cyclin C (Ser275) Rabbit pAb
中文名称
磷酸化周期素C抗体
英文别名
CCNC | Cyclin-C (phospho-S275); p-Cyclin-C; phospho-Cyclin-C; p-CCNC; CCNC | Cyclin-C (phospho-Ser275); CycC; SRB11; hSRB11; CG1C; CCNC_HUMAN; CCNC; SRB11 homolog (hSRB11); CCNC_MOUSE; CCNC_RAT;
抗体来源
Rabbit
免疫原
KLH conjugated Synthesised phosphopeptide derived from human Cyclin C around the phosphorylation site of Ser275: NG(p-S)QN
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
33 kDa
检测分子量
35 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
周期素 C属于高度保守的周期素家族。
不同的周期素出现在不同的细胞增殖周期。
能结合和激活CDK激酶。
周期素 C(Cyclin C)主要出现在G1期（第一间隙期（或生长期）（G1）：是在有丝分裂（M）和开始DNA合成（S）期之间的阶段；
周期素 C(Cyclin C)主要出现在G1期（第一间隙期（或生长期）（G1）：是在有丝分裂（M）和开始DNA合成（S）期之间的阶段；
背景资料
The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | Mouse, Rat, Sheep, Cow, Chicken, Dog, Horse | 1:500-2000 |
| IHC-P | Mouse, Rat | Human, Sheep, Cow, Chicken, Dog, Horse | 1:100-500 |
| IHC-F | Mouse, Rat | Human, Sheep, Cow, Chicken, Dog, Horse | 1:100-500 |
| IF | Mouse, Rat | Human, Sheep, Cow, Chicken, Dog, Horse | 1:100-500 |
交叉反应
交叉反应: Human, Mouse, Rat (predicted: Sheep, Cow, Chicken, Dog, Horse)
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靶标
基因名
CCNC
蛋白名
Cyclin-C
亚细胞定位
Nucleus.
组织特异性
Highest levels in pancreas. High levels in heart, liver, skeletal muscle and kidney. Low levels in brain.
翻译后修饰
Phosphorylated upon DNA damage, probably by ATM or ATR.
相似性
Belongs to the cyclin family. Cyclin C subfamily.
Contains 1 cyclin N-terminal domain.
Contains 1 cyclin N-terminal domain.
功能
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.
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