14-3-3 sigma Rabbit pAb (一抗) | Bioss
货号：bs-12422R
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概述
产品编号
bs-12422R
产品类型
宠物抗体、农牧业/家禽抗体
英文名称
14-3-3 sigma Rabbit pAb
中文名称
14-3-3 sigma抗体
英文别名
YWHAS; 1433S_HUMAN; SFN; Epithelial cell marker protein 1; Stratifin; HME1; 14-3-3 sigma
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human 14-3-3 sigma: 101-200/248
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
28 kDa
检测分子量
28 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料
This gene encodes a cell cycle checkpoint protein. The encoded protein binds to translation and initiation factors and functions as a regulator of mitotic translation. In response to DNA damage this protein plays a role in preventing DNA errors during mitosis. [provided by RefSeq, Aug 2017]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Rat | Human, Mouse, Rabbit, Pig, Sheep, Dog, Horse | 1:500-2000 |
交叉反应
交叉反应: Human, Rat (predicted: Mouse, Rabbit, Pig, Sheep, Dog, Horse)
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靶标
基因名
SFN
蛋白名
14-3-3 protein sigma
亚基
Homodimer. Interacts with KRT17 and SAMSN1 (By similarity). Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. Interacts with GAB2. Interacts with SRPK2. Interacts with COPS6. Interacts with RFWD2; this interaction leads to proteasomal degradation.
亚细胞定位
Cytoplasm. Nucleus. Secreted. May be secreted by a non-classical secretory pathway.
组织特异性
Present mainly in tissues enriched in stratified squamous keratinizing epithelium.
相似性
Belongs to the 14-3-3 family.
功能
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway.
p53-regulated inhibitor of G2/M progression.
p53-regulated inhibitor of G2/M progression.
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