The glycoprotein encoded by this gene is a cell surface antigen that is expressed in greater than 95% of human colon cancers. The open reading frame encodes a 319-amino acid polypeptide having a putative secretory signal sequence and 3 potential glycosylation sites. The predicted mature protein has a 213-amino acid extracellular region, a single transmembrane domain, and a 62-amino acid intracellular tail. The sequence of the extracellular region contains 2 domains characteristic of the CD2 subgroup of the immunoglobulin (Ig) superfamily. [provided by RefSeq, Jul 2008]
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
WB
Rat
Human, Mouse
1:500-2000
IHC-P
Human
Mouse, Rat
1:100-500
IHC-F
Human
Mouse, Rat
1:100-500
IF
Human
Mouse, Rat
1:100-500
交叉反应
交叉反应: Human, Rat (predicted: Mouse)
相关产品
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靶标
基因名
GPA33
蛋白名
Cell surface A33 antigen
亚细胞定位
Membrane; Single-pass type I membrane protein.
组织特异性
Expressed in normal gastrointestinal epithelium and in 95% of colon cancers.
翻译后修饰
N-glycosylated, contains approximately 8 kDa of N-linked carbohydrate.
Palmitoylated.