TAZ Rabbit pAb (一抗) - WB,IHC-P,IHC-F,IF,Flow-Cyt | Bioss
概述
The transcriptional co-activator with PDZ-binding motif (TAZ) is a 14-3-3-binding molecule. The highly conserved and ubiquitously expressed 14-3-3 proteins regulate differentiation, cell cycle progression and apoptosis by binding intracellular phosphoproteins involved in signal transduction. TAZ may link events at the plasma membrane and cytosketeton to nuclear transcription in a manner that can be regulated by 14-3-3. TAZ shares homology with the WW domain of Yes-associated protein (YAP) and functions as a transcriptional co-activator by binding to the PPXY motif present on transcription factors. TAZ recognizes immunoreactive protein bands in lysates from MDCK, NIH-3T3 and 293T cells. In addition, COS7, Hep G2, CHO and HeLa cells express endogenous TAZ. 14-3-3 binding requires TAZ phosphorylation on a single Serine 89 residue, resulting in the inhibition of TAZ transcriptional co-activation through 14-3-3-mediated nuclear export.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse, Rat | Pig, Sheep, Cow, Dog, Horse | 1:500-2000 |
| IHC-P | Mouse, Rat | Human, Pig, Sheep, Cow, Dog, Horse | 1:100-500 |
| IHC-F | Mouse, Rat | Human, Pig, Sheep, Cow, Dog, Horse | 1:100-500 |
| IF | Mouse, Rat | Human, Pig, Sheep, Cow, Dog, Horse | 1:100-500 |
| Flow-Cyt | Human | Mouse, Rat, Pig, Sheep, Cow, Dog, Horse | 3ug/test |
交叉反应
交叉反应: Human, Mouse, Rat (predicted: Pig, Sheep, Cow, Dog, Horse)
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