IL-10 Rabbit pAb (一抗) | Bioss
货号：bs-0698R
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概述
产品编号
bs-0698R
产品类型
农牧业/家禽抗体
英文名称
IL-10 Rabbit pAb
中文名称
白细胞介素10抗体
英文别名
CSIF; GVHDS; IL-10; IL10A; TGIF; If2a; IL10X; IL10_HUMAN; IL10; Cytokine synthesis inhibitory factor (CSIF); IL10_MOUSE; IL10_RAT;
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human IL-10: 101-178/178
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
18 kDa
检测分子量
21 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
白细胞介素-10(IL-10)是主要由Th2细胞所产生的一种细胞因子，活化的B细胞、单核巨噬细胞和枯否氏细胞（Kupffer's cell）等也可产生IL-10。它是以抑制Th细胞克隆细胞因子合成为特点的多效免疫调节因子。
白介素-10是维护细胞因子网络平衡的重要负调节因子。其作用机制可能是降低抗原递呈细胞MHCⅡ类抗原表达，或诱导抗原递呈细胞产生另一种细胞因子，改变细胞内信号传递途径，从而选择性抑制某些细胞因子mRNA转录，并与Th2细胞产生的IL-4、IL-5有协同作用。
背景资料
The protein encoded by this gene is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract. Mutations in this gene are associated with an increased susceptibility to HIV-1 infection and rheumatoid arthritis. [provided by RefSeq, May 2020]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | Mouse, Rat, Rabbit, Pig, Sheep, Chicken, GuineaPig | 1:500-2000 |
| IHC-P | Human, Mouse | Rat, Rabbit, Pig, Sheep, Chicken, GuineaPig | 1:100-500 |
| IHC-F | Human, Mouse | Rat, Rabbit, Pig, Sheep, Chicken, GuineaPig | 1:100-500 |
| IF | Human, Mouse | Rat, Rabbit, Pig, Sheep, Chicken, GuineaPig | 1:100-500 |
交叉反应
交叉反应: Human, Mouse (predicted: Rat, Rabbit, Pig, Sheep, Chicken, GuineaPig)
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靶标
基因名
IL10
蛋白名
Interleukin-10
亚基
Homodimer.
亚细胞定位
Secreted.
组织特异性
Produced by a variety of cell lines, including T-cells, macrophages, mast cells and other cell types.
相似性
Belongs to the IL-10 family.
功能
IL-10 protein is a cytokine produced primarily by monocytes and to a lesser extent by lymphocytes. This cytokine has pleiotropic effects in immunoregulation and inflammation. It down-regulates the expression of Th1 cytokines, MHC class II Ags, and costimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. This cytokine can block NF-kappa B activity, and is involved in the regulation of the JAK-STAT signaling pathway. Knockout studies in mice suggested the function of this cytokine as an essential immunoregulator in the intestinal tract.
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