14-3-3 Rabbit pAb (一抗) | Bioss
货号：bs-9654R
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概述
产品编号
bs-9654R
产品类型
模式动物抗体、农牧业/家禽抗体
英文名称
14-3-3 Rabbit pAb
中文名称
14-3-3/YWHAZ蛋白抗体
英文别名
GW128; HEL-S-1; HS1; KCIP-1; YWHAA; 14-3-3-zeta; HEL-S-3; HEL-S-93; HEL4; POPCHAS; YWHAD; 1110013I11Rik; 14-3-3zeta; 1300003C17Rik; 14-3-3b; 14-3-3z; 143B_BOVIN; 1433B_HUMAN; YWHAB; Protein 1054; Protein kinase C inhibitor protein 1 (KCIP-1); 1433Z_HUMAN; YWHAZ; 143Z_MOUSE; 1433B_MOUSE; 1433B_RAT; Prepronerve growth factor RNH-1; 1433Z_RAT; Mitochondrial import stimulation factor S1 subunit; Msfs1; 1433Z_SHEEP; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, delta polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, zeta polypeptide; 14-3-3 zeta; 14-3-3 delta
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human pan 14-3-3: 151-255/255
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
28 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
Cell Biology > Apoptosis > Intracellular > Associated Proteins
Cell Biology > Cell Cycle > Cell Division > Other cell division antibodies
Neuroscience > Cell Type Marker > Neuron marker > Synapse marker
Neuroscience > Neurology process > Neural Signal Transduction
Neuroscience > Neurology process > Neurodegenerative disease > Alzheimer's disease
Signal Transduction > Adapters > Cytoplasmic
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
信号传导（Signaling Intermediates）
14-3-3蛋白是一个涉及调节细胞凋亡、促细胞分裂信号传导和细胞周期关卡的蛋白质家族。它被认为是通过与丝氨酸残基磷酸化的蛋白质的结合介导的信号传导中的关键调节物。通过与Bad(相关死亡因子)的结合， 14-3-3 蛋白由于将Bad隔离于胞液而防止了细胞凋亡。
14-3-3 ζ 蛋白是14-3-3家族成员。它广泛分布于哺乳动物、两栖类、昆虫、植物和酵母菌的真核生物高度保守性多功能蛋白质。目前已知至少有16个成员。此抗体识别分子量为30-31kDa的14-3-3ζ蛋白亚型。
背景资料
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse, Rat, Sheep, Fruit Fly, Yeast | 1:500-2000 | |
| IHC-P | Mouse, Rat | Human, Sheep, Fruit Fly, Yeast | 1:100-500 |
| IHC-F | Mouse, Rat | Human, Sheep, Fruit Fly, Yeast | 1:100-500 |
| IF | Mouse, Rat | Human, Sheep, Fruit Fly, Yeast | 1:100-500 |
| Flow-Cyt | Human | Mouse, Rat, Sheep, Fruit Fly, Yeast | 1μg /test. |
交叉反应
交叉反应: Human, Mouse, Rat (predicted: Sheep, Fruit Fly, Yeast)
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靶标
基因名
YWHAZ
蛋白名
14-3-3 protein zeta/delta
亚基
Interacts with CDK16 and BSPRY. Interacts with WEE1 (C-terminal). Interacts with SAMSN1. Interacts with MLF1 (phosphorylated form); the interaction retains it in the cytoplasm. Interacts with Thr-phosphorylated ITGB2. Interacts with BCL2L11. Homodimer. Heterodimerizes with YWHAE. Homo- and hetero-dimerization is inhibited by phosphorylation on Ser-58. Interacts with FOXO4, NOXA1, SSH1 and ARHGEF2. Interacts with Pseudomonas aeruginosa exoS (unphosphorylated form). Interacts with BAX; the interaction occurs in the cytoplasm. Under stress conditions, MAPK8-mediated phosphorylation releases BAX to mitochondria. Interacts with phosphorylated RAF1; the interaction is inhibited when YWHAZ is phosphorylated on Thr-232. Interacts with TP53; the interaction enhances p53 transcriptional activity. The Ser-58 phosphorylated form inhibits this interaction and p53 transcriptional activity. Interacts with ABL1 (phosphorylated form); the interaction retains ABL1 in the cytoplasm. Interacts with PKA-phosphorylated AANAT; the interaction modulates AANAT enzymatic activity by increasing affinity for arylalkylamines and acetyl-CoA and protecting the enzyme from dephosphorylation and proteasomal degradation. It may also prevent thiol-dependent inactivation. Interacts with AKT1; the interaction phosphorylates YWHAZ and modulates dimerization. Interacts with GAB2 and TLK2.
亚细胞定位
Cytoplasm. Melanosome. Note=Located to stage I to stage IV melanosomes.
翻译后修饰
The delta, brain-specific form differs from the zeta form in being phosphorylated (By similarity). Phosphorylation on Ser-184 by MAPK8; promotes dissociation of BAX and translocation of BAX to mitochondria. Phosphorylation on Ser-58 by PKA; disrupts homodimerization and heterodimerization with YHAE and TP53. This phosphorylation appears to be activated by sphingosine. Phosphorylation on Thr-232; inhibits binding of RAF1.
相似性
Belongs to the 14-3-3 family.
功能
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
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