RPS6KB1 Rabbit pAb (一抗) | Bioss
货号：bs-6370R
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概述
产品编号
bs-6370R
产品类型
宠物抗体、农牧业/家禽抗体
英文名称
RPS6KB1 Rabbit pAb
中文名称
核糖体p70 S6蛋白激酶抗体
英文别名
PS6K; S6K; S6K-beta-1; S6K1; STK14A; p70 S6KA; p70(S6K)-alpha; p70-S6K; p70-alpha; 2610318I15Rik; P70S6K1; p70 S6K-alpha; p70-S6K 1; p70/85s6k; p70s6k; KS6B1_HUMAN; RPS6KB1; 70 kDa ribosomal protein S6 kinase 1 (P70S6K1 | p70-S6K 1); Ribosomal protein S6 kinase I; Serine/threonine-protein kinase 14A; p70 ribosomal S6 kinase alpha (p70 S6 kinase alpha | p70 S6K-alpha | p70 S6KA); 2.7.11.1; KS6B1_MOUSE; Ribosomal protein S6 kinase I (S6K); KS6B1_RAT; ribosomal protein S6 kinase B1; ribosomal protein S6 kinase, 70kD, polypeptide 1
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human RPS6KB1: 251-350/525
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
70 kDa
检测分子量
68 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
Cell Biology > Cell Cycle > Cell Cycle Inhibitors > Rb
Epigenetics and Nuclear Signaling > DNA / RNA > DNA Damage & Repair > DNA Damage Response > DNA Damage Recognition
Epigenetics and Nuclear Signaling > DNA / RNA > Translation > Ribosome
Metabolism > Types of disease > Obesity
Signal Transduction > Protein Phosphorylation > Ser / Thr Kinases > S6K Family
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. [provided by RefSeq, Jan 2013]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | Mouse, Rat, Rabbit, Pig, Cow, Chicken, Dog, Horse, Goat | 1:500-2000 |
| IHC-P | Rat | Human, Mouse, Rabbit, Pig, Cow, Chicken, Dog, Horse, Goat | 1:100-500 |
| IHC-F | Rat | Human, Mouse, Rabbit, Pig, Cow, Chicken, Dog, Horse, Goat | 1:100-500 |
| IF | Rat | Human, Mouse, Rabbit, Pig, Cow, Chicken, Dog, Horse, Goat | 1:100-500 |
交叉反应
交叉反应: Human, Rat (predicted: Mouse, Rabbit, Pig, Cow, Chicken, Dog, Horse, Goat)
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靶标
基因名
RPS6KB1
蛋白名
Ribosomal protein S6 kinase beta-1
亚基
Interacts with PPP1R9A/neurabin-1. Interacts with RPTOR. Interacts with IRS1. Interacts with EIF3B and EIF3C. Interacts with POLDIP3 and TRAF4.
亚细胞定位
Cytoplasm; Nucleus. Cytoplasm and Cell junction > synapse > synaptosome. Mitochondrion outer membrane.
组织特异性
Widely expressed.
翻译后修饰
Phosphorylation at Thr-412 is regulated by mTORC1. The phosphorylation at this site is maintained by an agonist-dependent autophosphorylation mechanism.
相似性
Belongs to the protein kinase superfamily.
AGC Ser/Thr protein kinase family. S6 kinase subfamily.
Contains 1 AGC-kinase C-terminal domain.
Contains 1 protein kinase domain.
AGC Ser/Thr protein kinase family. S6 kinase subfamily.
Contains 1 AGC-kinase C-terminal domain.
Contains 1 protein kinase domain.
功能
Acts to integrate nutrient and growth factor signals in regulation of protein synthesis, cell proliferation, cell growth, cell cycle progression and cell survival. Downstream effector of the mTOR signaling pathway. Phosphorylates specifically ribosomal protein S6 in response to insulin or several classes of mitogens. During translation initiation, the inactive form associatess with the eIF-3 complex under conditions of nutrient depletion. Mitogenic stimulation leads to phosphorylation and dissociation from the eIF-3 complex and the free activated form can phosphorylate other translational targets including EIF4B. Promotes protein synthesis by phosphorylating PDCD4 at 'Ser-67' and targeting it for degradation. Phosphorylates RICTOR leading to regulation of mammalian target of rapamycin complex 2 (mTORC2) signaling; probably phosphorylates RICTOR at 'Thr-1135'. Phosphorylates IRS1 at multiple serine residues coupled with insulin resistance; probably phosphorylates IRS1 at 'Ser-270'. Required for TNF-alpha induced IRS-1 degradation. Phosphorylates EEF2K in response to IGF1 and inhibits EEF2K activity. Phosphorylates BAD at 'Ser-99' in response to IGF1 leading to BAD inactivation and inhibition of BAD-induced apoptosis. Phosphorylates mitochondrial RMP leading to dissociation of a RMP:PPP1CC complex; probably phosphorylates RMP at 'Ser-99'. The free mitochondrial PPP1CC can dephosphorylate RPS6KB1 at Thr-412 which is proposed to be a negative feed back mechanism for the RPS6KB1 antiapoptotic function. Phosphorylates GSK3B at 'Ser-9' under conditions leading to loss of the TSC1-TSC2 complex. Phosphorylates POLDIP3.
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