ADGRE1 Rabbit pAb (一抗) - WB,Flow-Cyt | Bioss

bs-41204R

ADGRE1 Rabbit pAb

表皮生长因子样激素受体1（EMR1）抗体

AGRE1_HUMAN; ADGRE1; EGF-like module receptor 1; EGF-like module-containing mucin-like hormone receptor-like 1; EMR1 hormone receptor; EMR1; TM7LN3; AGRE1_MOUSE; Cell surface glycoprotein F4/80; Gpf480; adhesion G protein-coupled receptor E1; egf-like module containing, mucin-like, hormone receptor-like sequence 1; egf-like module containing, mucin-like, hormone receptor-like 1

Rabbit

Recombinant human ADGRE1: 241-530/886

IgG

Liquid

affinity purified by Protein A

Polyclonal

95 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

The epidermal growth factor (EGF)-TM7 family constitutes a group of class B G-protein coupled receptors, which includes CD97, EMR1 (EGF-like molecule containing mucin-like hormone receptor 1, designated F4/80 in mouse), EMR2, EMR3, FIRE, and ETL (1–3). These family members are characterized by an extended extracellular region with several N-terminal EGF domains, and are predominantly expressed on cells of the immune system (1–3). The EGF-TM7 protein family are encoded by a gene cluster on human chromosome 19p13 (1,3,4). The F4/80 molecule is solely expressed on the surface of macrophages and serves as a marker for mature macrophage tissues, including Kupffer cells in liver, splenic red pulp macrophages, brain microglia, gut lamina propria, and Langerhans cells in the skin (1). F4/80/EMR1 undergoes extensive N-linked glycosylation as well as some O-linked glycosylation (5,6). The function of F4/80/EMR1 is unclear, but it is speculated to be involved in macrophage adhesion events, cell migration, or as a G-protein coupled signaling component of macrophages.