单纯疱疹病毒糖蛋白D抗体

货号:bs-18094R
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概述

产品编号
bs-18094R
英文名称
HSV1 gD Rabbit pAb
中文名称
单纯疱疹病毒糖蛋白D抗体
英文别名
GD; Glycoprotein D; GD_HHV1A; Herpes simplex virus type 1 glycoprotein D; HSV1 glycoprotein D; US6.; gD;
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from HSV1 gD, strain Angelotti: 26-100/394
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
41 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料
Herpes simplex type 1 (HSV-1) belongs to a family that includes HSV-2, Epstein-Barr virus (EBV) and Varicella zoster (chicken pox) virus amongst others. HSV-1 and HSV-2 are extremely difficult to distinguish from each other. Members of this family have a characteristic virion structure. The double stranded DNA genome is contained within an icosahedral capsid embedded in a proteinaceous layer (tegument) and surrounded by a lipid envelope, derived from the nuclear membrane of the last host, which is decorated with virus-specific glycoproteins spikes. These viruses are capable of entering a latent phase where the host shows no visible sign of infection and levels of infectious agent become very low. During the latent phase the viral DNA is integrated into the genome of the host cell.

产品应用

应用已检合格种属预测种属推荐稀释比例
WBHerpes Simplex Virus1:500-2000
IHC-PHerpes Simplex Virus1:100-500
IHC-FHerpes Simplex Virus1:100-500
IFHerpes Simplex Virus1:100-500
ICC/IFHerpes Simplex Virus1:100-500
ELISAHerpes Simplex Virus1:5000-10000

交叉反应

交叉反应: (predicted: Herpes Simplex Virus)

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靶标

基因名
RL1
蛋白名
Neurovirulence factor ICP34.5
亚基
Interacts with human PPP1CA to form a high-molecular-weight complex that dephosphorylates eIF2-alpha. Binds to host PCNA, which may release host cells from growth arrest and facilitate viral replication.
亚细胞定位
Host cytoplasm. Host nucleus, host nucleolus. Virion. Note=At early times in infection, colocalizes with PCNA and replication proteins in cell nuclei, before accumulating in the cytoplasm by 8 to 12 hours post-infection. The effects on the host cell are mediated by de novo-synthesized ICP34.5, the virion-derived population being either non-functional or present in very low amounts.
相似性
Belongs to the PPP1R15 family.
功能
Contributes to HSV resistance to the antiviral effects of alpha/beta interferon. Recruits the serine/threonine-protein phosphatase PPP1CA/PP1-alpha to dephosphorylate the translation initiation factor eIF-2A, thereby couteracting the host shutoff of protein synthesis involving double-stranded RNA-dependent protein kinase EIF2AK2/PKR. Also down-modulates the host MHC class II proteins cell surface expression. Acts as a neurovirulence factor that has a profound effect on the growth of the virus in central nervous system tissue, probably through its ability to maintain an environment favorable for viral replication.

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