APC标记的整合素αM单克隆抗体

货号:bsm-54156R-APC
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概述

产品编号
bsm-54156R-APC
英文名称
CD11b Recombinant Rabbit mAb, APC conjugated
中文名称
APC标记的整合素αM单克隆抗体
英文别名
CD11B; CR3A; MAC-1; MAC1A; MO1A; SLEB6; ITAM_HUMAN; ITGAM; CD11 antigen-like family member B; CR-3 alpha chain; Cell surface glycoprotein MAC-1 subunit alpha; Leukocyte adhesion receptor MO1; Neutrophil adherence receptor; ITAM_MOUSE;
标记
APC
Excitation spectrum: 650nm
Emission spectrum: 660nm
抗体来源
Rabbit
免疫原
Recombinant Human ITGAM
亚型
IgG
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
9B3
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
背景资料
This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

产品应用

应用已检合格种属预测种属推荐稀释比例
IFHuman1:200-800

交叉反应

交叉反应: Human

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靶标

基因名
ITGAM
蛋白名
Integrin alpha-M
亚基
Heterodimer of an alpha and a beta subunit. Alpha-M associates with beta-2. Interacts with JAM3.
亚细胞定位
Membrane.
组织特异性
Predominantly expressed in monocytes and granulocytes.
疾病
Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6) [MIM:609939]. Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.
相似性
Genetic variations in ITGAM has been associated with susceptibility to systemic lupus erythematosus type 6 (SLEB6). Systemic lupus erythematosus (SLE) is a chronic, inflammatory and often febrile multisystemic disorder of connective tissue. It affects principally the skin, joints, kidneys and serosal membranes. It is thought to represent a failure of the regulatory mechanisms of the autoimmune system.
功能
Integrin alpha-M/beta-2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin alpha-M/beta-2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain.

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