TNF-alpha Recombinant Rabbit mAb (一抗) - WB,IHC-P,IHC-F,IF,IP | Bioss
Rrmab?兔单抗
货号：bsm-55603R
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概述
产品编号
bsm-55603R
产品类型
重组兔单抗
英文名称
TNF-alpha Recombinant Rabbit mAb
中文名称
肿瘤坏死因子-α重组兔单抗
英文别名
DIF; IMD127; TNF-alpha; TNFA; TNFSF2; TNLG1F; TNF-a; TNFalpha; Tnfsf1a; TNFA_HUMAN; TNF; Cachectin; Tumor necrosis factor ligand superfamily member 2 (TNF-a); TNFA_MOUSE; TNFA_CANLF; TNFA_RAT; RATTNF; tumor necrosis factor; tumor necrosis factor (TNF superfamily, member 2); TNF superfamily, member 2
抗体来源
Rabbit
免疫原
Recombinant human TNF alpha protein
亚型
IgG,Kappa
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Recombinant
克隆号
12A7
理论分子量
26 kDa
检测分子量
25 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
Cancer > Growth factors > TNF
Cardiovascular > Atherosclerosis > Vascular Inflammation > Inflammatory mediators
Immunology > Innate Immunity > Cytokines > TNF Superfamily
Metabolism > Types of disease > Metabolic disorders
Microbiology > Organism > Virus > RNA Virus > ssRNA positive strand virus > SARS Coronavirus
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
产品介绍
生长因子和激素
肿瘤坏死因子-TNF α是巨嗜细胞感染时或应激情况下自然产生的一种十分活跃的生物活性因子，可能与干扰素协同作用杀伤瘤细胞。
肿瘤坏死因子-TNF α是巨嗜细胞感染时或应激情况下自然产生的一种十分活跃的生物活性因子，可能与干扰素协同作用杀伤瘤细胞。
背景资料
This gene encodes a multifunctional proinflammatory cytokine that belongs to the tumor necrosis factor (TNF) superfamily. This cytokine is mainly secreted by macrophages. It can bind to, and thus functions through its receptors TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. This cytokine is involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. This cytokine has been implicated in a variety of diseases, including autoimmune diseases, insulin resistance, psoriasis, rheumatoid arthritis ankylosing spondylitis, tuberculosis, autosomal dominant polycystic kidney disease, and cancer. Mutations in this gene affect susceptibility to cerebral malaria, septic shock, and Alzheimer disease. Knockout studies in mice also suggested the neuroprotective function of this cytokine. [provided by RefSeq, Aug 2020]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | Mouse, Rat | 1:500-2000 |
| IHC-P | Human, Mouse, Rat | 1:100-500 | |
| IHC-F | Human, Mouse, Rat | 1:100-500 | |
| IF | Human, Mouse, Rat | 1:100-500 | |
| IP | Human, Mouse, Rat | 1:50-100 |
交叉反应
交叉反应: Human (predicted: Mouse, Rat)
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靶标
基因名
TNF
蛋白名
Tumor necrosis factor
亚基
Homotrimer. Interacts with SPPL2B.
亚细胞定位
Cell membrane; Single-pass type II membrane protein.
Tumor necrosis factor, membrane form: Membrane; Single-pass type II membrane protein.
Tumor necrosis factor, soluble form: Secreted.
C-domain 1: Secreted.
C-domain 2: Secreted.
Tumor necrosis factor, membrane form: Membrane; Single-pass type II membrane protein.
Tumor necrosis factor, soluble form: Secreted.
C-domain 1: Secreted.
C-domain 2: Secreted.
翻译后修饰
The soluble form derives from the membrane form by proteolytic processing. The membrane-bound form is further proteolytically processed by SPPL2A or SPPL2B through regulated intramembrane proteolysis producing TNF intracellular domains (ICD1 and ICD2) released in the cytosol and TNF C-domain 1 and C-domain 2 secreted into the extracellular space.
The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1.
O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid.
The membrane form, but not the soluble form, is phosphorylated on serine residues. Dephosphorylation of the membrane form occurs by binding to soluble TNFRSF1A/TNFR1.
O-glycosylated; glycans contain galactose, N-acetylgalactosamine and N-acetylneuraminic acid.
疾病
Genetic variations in TNF are a cause of susceptibility psoriatic arthritis (PSORAS) [MIM:607507]. PSORAS is an inflammatory, seronegative arthritis associated with psoriasis. It is a heterogeneous disorder ranging from a mild, non-destructive disease to a severe, progressive, erosive arthropathy. Five types of psoriatic arthritis have been defined: asymmetrical oligoarthritis characterized by primary involvement of the small joints of the fingers or toes; asymmetrical arthritis which involves the joints of the extremities; symmetrical polyarthritis characterized by a rheumatoidlike pattern that can involve hands, wrists, ankles, and feet; arthritis mutilans, which is a rare but deforming and destructive condition; arthritis of the sacroiliac joints and spine (psoriatic spondylitis).
相似性
Belongs to the tumor necrosis factor family.
功能
Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation.
The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.
The TNF intracellular domain (ICD) form induces IL12 production in dendritic cells.
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