Recombinant Human GSTT1 Protein, N-His (重组蛋白) | Bioss

货号:bs-104782P
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概述

产品编号
bs-104782P
英文名称
Recombinant Human GSTT1 Protein, N-His
英文别名
GST class-theta-1; Glutathione S-transferase theta-1; Glutathione transferase T1-1; GSTT1
性状
Lyophilized
纯化方法
AC
理论分子量
29.5 kDa
储存液
Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
SWISS
Gene ID
活性
Not tested
序列
1-240/240
物种
Human
标签
N-His
纯度
>90% as determined by SDS-PAGE.
表达系统
E.coli
复溶
Reconstitute in sterile water for a stock solution.
保存条件
Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at -20 to -80°C for twelve months from the date of receipt.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料
Glutathione S-transferase (GST) theta 1 (GSTT1) is a member of a superfamily of proteins that catalyze the conjugation of reduced glutathione to a variety of electrophilic and hydrophobic compounds. Human GSTs can be divided into five main classes: alpha, mu, pi, theta, and zeta. The theta class includes GSTT1 and GSTT2. The GSTT1 and GSTT2 share 55% amino acid sequence identity and both of them were claimed to have an important role in human carcinogenesis. The GSTT1 gene is located approximately 50kb away from the GSTT2 gene. The GSTT1 and GSTT2 genes have a similar structure, being composed of five exons with identical exon/intron boundaries. [provided by RefSeq, Jul 2008].

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靶标

基因名
GSTT1
蛋白名
Glutathione S-transferase theta-1
亚基
Homodimer.
亚细胞定位
Cytoplasm.
组织特异性
Found in erythrocyte. Expressed at low levels in liver. In lung, expressed at low levels in Clara cells and ciliated cells at the alveolar/bronchiolar junction. Absent from epithelial cells of larger bronchioles.
相似性
Belongs to the GST superfamily. Theta family.
Contains 1 GST C-terminal domain.
Contains 1 GST N-terminal domain.
功能
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Acts on 1,2-epoxy-3-(4-nitrophenoxy)propane, phenethylisothiocyanate 4-nitrobenzyl chloride and 4-nitrophenethyl bromide. Displays glutathione peroxidase activity with cumene hydroperoxide.

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