PerCP-Cy5.5标记的刺激分子B7-1蛋白抗体

货号:bs-2211R-PerCP-Cy5.5
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概述

产品编号
bs-2211R-PerCP-Cy5.5
英文名称
CD80 Rabbit pAb, PerCP-Cy5.5 conjugated
中文名称
PerCP-Cy5.5标记的刺激分子B7-1蛋白抗体
英文别名
Activation B7-1 antigen; B lymphocyte activation antigen B7; B7; B7-1; B7-1 antigen; BB1; CD28 antigen ligand 1; CD28LG; CD28LG1; CD80; CD80 antigen(CD28 antigen ligand 1, B7-1 antigen); CD80 antigen; CD80 molecule; CD80_HUMAN; Costimulatory factor CD80; costimulatory molecule variant IgV-CD80; CTLA-4 counter-receptor B7.1; LAB7; T-lymphocyte activation antigen CD80; CD80_RAT.
标记
PerCP-Cy5.5
Excitation spectrum: 482nm
Emission spectrum: 694nm
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from rat CD80: 251-321/321 <Cytoplasmic>
亚型
IgG
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
背景资料
CD80 is a member of the Ig superfamily and serves as the ligand for two T cell molecules, CD28 and CTLA4. Interactions between CD28 and CD80 on activated B cells result in enhanced T cell activation. CD80 is rapidly induced on the surface of in vitro activated B cells, Epstein Barr Virus (EBV) transformed B cell lines, Burkitts lymphoma cell lines, freshly isolated follicular B lymphoma cells, T cells, and monocytes. It is also expressed at high levels in dendritic cells. It reacts weakly with a small proportion of non activated normal B cells and with HTLV1 infected T cells. CD80 does not react with peripheral monocytes, resting and activated normal T cells, T cell lines and T cell clones, nor with myelomonocytic cell lines.

产品应用

应用已检合格种属预测种属推荐稀释比例
Flow-CytHuman, Mouse, Rat1ug/test

交叉反应

交叉反应: Human, Mouse, Rat

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靶标

基因名
CD80
蛋白名
T-lymphocyte activation antigen CD80
亚细胞定位
Membrane; Single-pass type I membrane protein.
组织特异性
Expressed on activated B-cells, macrophages and dendritic cells.
相似性
Contains 1 Ig-like C2-type (immunoglobulin-like) domain.
Contains 1 Ig-like V-type (immunoglobulin-like) domain.
功能
Involved in the costimulatory signal essential for T lymphocytes activation. T-cell proliferation and cytokine production is induced by the binding of CD28 or CTLA-4 to this receptor.

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