CD80 is a member of the Ig superfamily and serves as the ligand for two T cell molecules, CD28 and CTLA4. Interactions between CD28 and CD80 on activated B cells result in enhanced T cell activation. CD80 is rapidly induced on the surface of in vitro activated B cells, Epstein Barr Virus (EBV) transformed B cell lines, Burkitts lymphoma cell lines, freshly isolated follicular B lymphoma cells, T cells, and monocytes. It is also expressed at high levels in dendritic cells. It reacts weakly with a small proportion of non activated normal B cells and with HTLV1 infected T cells. CD80 does not react with peripheral monocytes, resting and activated normal T cells, T cell lines and T cell clones, nor with myelomonocytic cell lines.
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
Flow-Cyt
Human, Mouse, Rat
1ug/test
交叉反应
交叉反应: Human, Mouse, Rat
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靶标
基因名
CD80
蛋白名
T-lymphocyte activation antigen CD80
亚细胞定位
Membrane; Single-pass type I membrane protein.
组织特异性
Expressed on activated B-cells, macrophages and dendritic cells.
Involved in the costimulatory signal essential for T lymphocytes activation. T-cell proliferation and cytokine production is induced by the binding of CD28 or CTLA-4 to this receptor.