This gene encodes an integral membrane protein which is located at tight junctions. This protein may be involved in the formation and maintenance of the tight junction. The possibility of several alternatively spliced products has been suggested but the full nature of these products has not been described. [provided by RefSeq].
Localized at tight junctions of both epithelial and endothelial cells. Highly expressed in kidney. Not detected in testis.
翻译后修饰
Phosphorylated upon DNA damage, probably by ATM or ATR. Dephosphorylated by PTPRJ. May be phosphorylated by PKC during translocation to cell-cell contacts.
相似性
Belongs to the ELL/occludin family.
Contains 1 MARVEL domain.
功能
May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.