Islet-1 Rabbit pAb (一抗) | Bioss
概述
Cardiovascular > Atherosclerosis > Diabetes associated
Cardiovascular > Heart > Cardiogenesis > Transcription factors/regulators
Developmental Biology > Lineage specification > Endoderm
Developmental Biology > Organogenesis > Gut development > Pancreas development
Neuroscience > Cell Type Marker > Neuron marker > Soma marker
Neuroscience > Neurology process > Neurogenesis
Stem Cells > Lineage Markers > Endoderm
Islet-1 and Islet-2 contain amino-terminal LIM domains and a carboxy-terminal homeodomain and both influence developmental events. Islet-1 influences embryogenesis of the pancreatic islets of Langerhans and neural tube motor neuron differentiation. In developing mouse teeth, Islet-1 mediates patterning of dentition as an activator of Bmp4 expression in incisor (distal) areas of the stomatodeal epithelium. Islet-1 expression defines cardiac progenitor cell populations and is required for normal cardiac development and asymmetry. Islet-2 activity in newly generated motor neurons permits the diversification of visceral and somatic motor neuron subtypes in the developing spinal cord. Murine Islet-2 specifies retinal ganglion cell (RGC) laterality by repressing an ipsilateral pathfinding program unique to the ventral-temporal crescent (VTC) of RGCs in a Zic2- and EphB1-dependent manner.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | Mouse, Rat, Sheep, Cow, Horse | 1:500-2000 |
| IHC-P | Mouse, Rat | Human, Sheep, Cow, Horse | 1:100-500 |
| IHC-F | Mouse, Rat | Human, Sheep, Cow, Horse | 1:100-500 |
| IF | Mouse, Rat | Human, Sheep, Cow, Horse | 1:100-500 |
交叉反应
交叉反应: Human, Mouse, Rat (predicted: Sheep, Cow, Horse)
相关产品
暂无相关产品
靶标
Contains 2 LIM zinc-binding domains.