IgG-Fc片断受体转运蛋白α抗体

bs-13151R

宠物抗体、农牧业/家禽抗体

FCGRT Rabbit pAb

IgG-Fc片断受体转运蛋白α抗体

FCRN; FcgammaRn; alpha-chain; FCGRN_HUMAN; FCGRT; IgG Fc fragment receptor transporter alpha chain; Neonatal Fc receptor;

Rabbit

KLH conjugated synthetic peptide derived from human FCGRT/FcRn: 51-150/365 <Extracellular>

Liquid

affinity purified by Protein A

Polyclonal

37 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

FcRN present in the intestinal epithelium of neonatal mice and rats mediates the selective uptake of immunoglobulin G (IgG) in mothers' milk, thereby helping newborn animals to acquire passive immunity. FcRn (also designated FCGRT, Brambell receptor, FcRn å chain, IgG Gc receptor and neonatal Fc-receptor) is comprised of a heavy chain and ∫-2-Microglobulin. FcRn heavy chain shows approximately 35% amino acid identity to an MHC class I molecule. FcRN localizes in endosomes of vascular endothelial cells and selectively recycles IgG to the cell surface, thus protecting IgG from lysosomal catabolism. This protection mechanism is a major constituent for ensuring IgG are the longest lived of all plasma proteins.