FBXO2 Rabbit pAb (一抗) | Bioss
货号：bs-13149R
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概述
产品编号
bs-13149R
产品类型
宠物抗体、农牧业/家禽抗体
英文名称
FBXO2 Rabbit pAb
中文名称
F-box蛋白2抗体
英文别名
FBG1; FBX2; Fbs1; NFB42; OCP1; Fbs2; Prpl4; FBX2_HUMAN; FBXO2; FBX2_MOUSE; F-box protein 2; F-box only protein 2; organ of Corti protein 1
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human FBXO2: 121-220/296
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
33 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
FBXO2 is a 296 amino acid protein that contains one F-box domain and one F-box associated domain. Functioning as a component of the SCF complex, FBXO2 is thought to recognize and bind to select phosphorylated proteins, thereby promoting their ubiquitination and subsequent degradation.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| IHC-P | Human, Mouse, Rat | Pig, Sheep, Cow, Dog | 1:100-500 |
| IHC-F | Human, Mouse, Rat | Pig, Sheep, Cow, Dog | 1:100-500 |
| IF | Human, Mouse, Rat | Pig, Sheep, Cow, Dog | 1:100-500 |
交叉反应
交叉反应: Human, Mouse, Rat (predicted: Pig, Sheep, Cow, Dog)
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靶标
基因名
FBXO2
蛋白名
F-box only protein 2
亚基
Component of the SCF(FBXO2) complex consisting of CUL1, RBX1, SKP1 and FBXO2. Predominantly detected as heterodimer with SKP1; the heterodimer with SKP1 is not part of the SCF(FBXO2) complex (By similarity).
亚细胞定位
Cytoplasm. Microsome membrane.
相似性
Contains 1 F-box domain.
Contains 1 FBA (F-box associated) domain.
Contains 1 FBA (F-box associated) domain.
功能
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Involved in the endoplasmic reticulum-associated degradation pathway (ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranslocated into the cytosol and promoting their ubiquitination and subsequent degradation. Prevents formation of cytosolic aggregates of unfolded glycoproteins that have been retrotranslocated into the cytosol. Able to recognize and bind denatured glycoproteins, preferentially those of the high-mannose type.
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