重组猪乙脑病毒(JEV)NS1蛋白

bs-41388P

Recombinant JEV NS1 protein, N-His

重组猪乙脑病毒(JEV)NS1蛋白

Japanese encephalitis virus,JEV NS1 protein; JEV-NS1; POLG_JAEVJ; Japanese encephalitis virus NS1 protein; Japanese encephalitis virus (JEV) NS1 protein;

Lyophilized or Liquid

AC

40

46 kDa

＞0.5 mg/ml

4M Urea (pH7.5) with 1mM DDT.

Not tested

795-1146/3432

N-His

>90% as determined by SDS-PAGE

Not analyzed

E.coli

Centrifuge tubes before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.

Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

猪乙型脑炎是由日本乙型脑炎病毒引起的人畜共患传染病，俗称“乙脑”,病毒依靠蚊子进行传播,具有严格的季节性。各种年龄、品种、性别的猪均易感染此病。猪感染本病后，母猪常发生流产、死胎，公猪发生睾丸炎，育肥猪可持续高热，仔猪常呈脑炎症状。 猪乙脑病毒结构蛋白是病毒粒子的主要成分, 也是维持形态结构的主要物质，结构蛋白包括衣壳蛋白C、毒粒包膜蛋白M (由P reM 切割而来) 和包膜蛋白E.

Involved in immune evasion, pathogenesis and viral replication. Once cleaved off the polyprotein, is targeted to three destinations: the viral replication cycle, the plasma membrane and the extracellular compartment. Essential for viral replication. Required for formation of the replication complex and recruitment of other non-structural proteins to the ER-derived membrane structures. Excreted as a hexameric lipoparticle that plays a role against host immune response. Antagonizing the complement function. Binds to the host macrophages and dendritic cells. Inhibits signal transduction originating from Toll-like receptor 3 (TLR3).