Luteinizing Hormone is a member of the glycoprotein hormone family. Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. LH is expressed in the pituitary gland and promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids. Mutations in the Luteinizing Hormone (LHB) gene are associated with hypogonadism which is characterized by infertility and pseudohermaphroditism.
产品应用
产品应用: ELISA=1:5000-10000, ICA
交叉反应
交叉反应: Human
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靶标
基因名
LHB
蛋白名
Lutropin subunit beta
亚基
Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.
亚细胞定位
Secreted.
组织特异性
Pituitary gland.
疾病
Hypogonadism LHB-related (HGON-LHB) [MIM:152780]: Characterized by infertility and pseudohermaphroditism. Note=The disease is caused by mutations affecting the gene represented in this entry.
相似性
Belongs to the glycoprotein hormones subunit beta family.
功能
Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.