GABA A receptor pi Rabbit pAb (一抗) | Bioss
货号：bs-13257R
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概述
产品编号
bs-13257R
产品类型
农牧业/家禽抗体
英文名称
GABA A receptor pi Rabbit pAb
中文名称
G氨基丁酸受体pi/GABAA Rπ抗体
英文别名
GBRP_BOVIN; GABRP; GABA(A) receptor subunit pi (GABAAR subunit pi); GBRP_HUMAN; GBRP_MOUSE; GBRP_RAT;
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human GABRP/GABA A receptor pi: 81-180/440 <Extracellular>
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
49 kDa
检测分子量
49 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
GAD-65 and GAD-67, glutamate decarboxylases function to catalyze the production of GABA (Gamma-aminobutyric acid). In the central nervous system GABA functions as the main inhibitory transmitter by increasing a Cl-conductance that inhibits neuronal firing. GABA has been shown to activate both ionotropic (GABAA) and metabotropic (GABAB) receptors as well as a third class of receptors called GABAC. Both GABAA and GABAC are ligand-gated ion channels, however, they are structurally and functionally distinct.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Mouse | Human, Rat, Rabbit, Pig, Sheep, Cow, Horse | 1:500-2000 |
交叉反应
交叉反应: Mouse (predicted: Human, Rat, Rabbit, Pig, Sheep, Cow, Horse)
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靶标
基因名
GABRP
蛋白名
gamma-aminobutyric acid receptor subunit pi
亚细胞定位
Cell junction; synapse; postsynaptic cell membrane. Cell membrane.
组织特异性
Most abundant in the uterus, also expressed in lung, thymus and prostate.
相似性
Belongs to the ligand-gated ion channel (TC 1.A.9) family.
Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRP sub-subfamily.
Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRP sub-subfamily.
功能
GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. In the uterus, the function of the receptor appears to be related to tissue contractility. The binding of this pI subunit with other GABA(A) receptor subunits alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone.
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