ORP150 Antibody Blocking Peptide (合成多肽) | Bioss

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货号：bs-4248P
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概述

产品编号
bs-4248P
英文名称
ORP150 Antibody Blocking Peptide
中文名称
氧气调节蛋白150封闭多肽
英文别名
150 kDa oxygen regulated protein; 150 kDa oxygen-regulated protein; 170 kDa glucose regulated protein; 170 kDa glucose-regulated protein; DKFZp686N08236; FLJ94899; FLJ97572; glucose regulated protein 170; Grp 170; GRP-170; Grp170; HSP 12A; HSP12A; Hyou1; HYOU1_HUMAN; Hypoxia up regulated 1; hypoxia up-regulated 1 precursor; Hypoxia up-regulated protein 1; Hypoxia upregulated 1; Orp 150; ORP-150; Orp150; oxygen regulated protein (150kD).
纯化方法
HPLC
研究领域

Cancer > Cancer Metabolism > Response to hypoxia

Cancer > Invasion/microenvironment > Hypoxia > Hypoxia-related proteins

Cardiovascular > Hypoxia > Associated Proteins

Epigenetics and Nuclear Signaling > Cardiovascular/Immune > Hypoxia > Hypoxia regulated

Metabolism > Pathways and Processes > Metabolism processes > Hypoxia

Neuroscience > Neurology process > Neurodegenerative disease

Signal Transduction > Protein Trafficking > Chaperones > Other Chaperones

Signal Transduction > Protein Trafficking > ER Proteins

活性
Not tested
保存条件
Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接

Entrez Gene : 10525 Human

Entrez Gene : 12282 Mouse

Entrez Gene : 192235 Rat

Omim : 601746 Human

SwissProt : Q9Y4L1 Human

SwissProt : Q9JKR6 Mouse

SwissProt : Q63617 Rat

Unigene : 277704 Human

背景资料
ORP150 (150KDa Oxygen-regulated Protein) is a member of the heat shock protein/stress protein family and has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. This protein has also been described as a molecular chaperone, induced by various environmental and physiological stimuli, and participates in protein folding in the endoplasmic reticulum. Furthermore, ORP150 is up-regulated in tumors and, in breast tumors, may be associated with tumor invasiveness.

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靶标

基因名
HYOU1
蛋白名
Hypoxia up-regulated protein 1
亚基
Part a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX.
亚细胞定位
Endoplasmic reticulum lumen.
组织特异性
Highly expressed in tissues that contain well-developed endoplasmic reticulum and synthesize large amounts of secretory proteins. Highly expressed in liver and pancreas and lower expression in brain and kidney. Also expressed in macrophages within aortic atherosclerotic plaques, and in breast cancers.
相似性
Belongs to the heat shock protein 70 family.
功能
Has a pivotal role in cytoprotective cellular mechanisms triggered by oxygen deprivation. May play a role as a molecular chaperone and participate in protein folding.

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