Cyclin E is a regulatory subunit of Cdk2 and controls G1 / S transition during the mammalian cell cycle. Multiple isoforms of Cyclin E are only expressed in tumors but not in normal tissue, suggesting a post transcriptional regulation of Cyclin E. In vitro analyses indicated that these truncated variant isoforms of Cyclin E are able to phosphorylate histone H1. Alterations in the Cyclin E protein have been implicated as indicators of worse prognosis in various cancers.

靶标

基因名

CCNE1

蛋白名

G1/S-specific cyclin-E1

亚基

Interacts with a member of the CDK2/CDK protein kinases to form a serine/threonine kinase holoenzyme complex. The cyclin subunit imparts substrate specificity to the complex. Found in a complex with CDK2, CABLES1 and CCNA1 (By similarity). Part of a complex consisting of UHRF2, CDK2 and CCNE1. Interacts directly with UHRF2; the interaction ubiquitinates CCNE1 and appears to occur independently of CCNE1 phosphorylation.

亚细胞定位

Nucleus.

组织特异性

Highly expressed in testis and placenta. Low levels in bronchial epithelial cells.

翻译后修饰

Phosphorylation of Thr-395 by GSK3 and of Ser-399 by CDK2 accelerates degradation via the ubiquitin proteasome pathway. Phosphorylated upon DNA damage, probably by ATM or ATR.

相似性

Belongs to the cyclin family. Cyclin E subfamily.

功能

Essential for the control of the cell cycle at the G1/S (start) transition.

Cyclin E Antibody Blocking Peptide (合成多肽) | Bioss

概述

相关产品

靶标

同靶标产品

相关文献

常见问题