口蹄疫病毒O型VP1

bs-41049P

Recombinant FMDV VP1 (type O) protein, Sumo & His

口蹄疫病毒O型VP1

foot and mouth disease virus; Foot-and-mouth disease virus-type O; VP1 protein; FMDV Polyprotein (VP1 protein); FMDV VP1; Recombinant FMDV VP1 (type O) protein, Sumo & His

Lyophilized or Liquid

AC

45

45 kDa

＞0.5 mg/ml

20mM Tris-HCl (pH7.5) with 8M Urea.

Not tested

726-935/2332

Sumo & His

>95% as determined by SDS-PAGE

Not analyzed

E.coli

Centrifuge tubes before opening. Reconstituting to a concentration more than 100 μg/ml is recommended. Dissolve the lyophilized protein in distilled water.

Stored at -70℃ or -20℃. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

口蹄疫是牛、羊、猪等的一种急性、热性传染病，人也可感染，是一种人兽患病。猪口蹄疫的临床特征是在蹄冠、趾间、蹄踵皮肤发生水疱和烂斑，部病猪口腔粘膜和鼻盘也有同样变化。有一种单纯性猪口蹄疫，只引起猪发病，牛、羊极少感染发病，其症状和一般口蹄疫相同。口蹄疫的病原体是口蹄疫病毒，为7个主型，即甲型（A型）、乙型（O型）、丙型（C型）、南非1型、南非2型、南非3型和亚洲1型，其中以甲型和乙型布最广，危害最大，单纯性猪口蹄疫是由乙型病毒所引起，以各型病毒接种动物，只对本型产生免疫力，没有交叉保护作用。

The foot-and-mouth disease virus (FMDV) is the pathogen that causes foot-and-mouth disease. It is a picornavirus, the prototypical member of the Aphthovirus genus. The disease, which causes vesicles (blisters) in the mouth and feet of bovids, suids, ovids, caprids and other cloven-hoofed animals is highly infectious and a major plague of animal farming. The virus particle (25-30 nm) has an icosahedral capsid made of protein, without envelope, containing a single strand of ribonucleic acid (RNA) containing a positive encoding of its genome. When the virus comes in contact with the membrane of a host cell, it binds to a receptor site and triggers a folding-in of the membrane. Once the virus is inside the host cell, the capsid dissolves, and the RNA gets replicated, and translated into viral proteins by the cell's ribosomes using a cap-independent mechanism driven by the internal ribosome entry site element. The foot-and-mouth disease virus occurs in seven major serotypes: O, A, C, SAT-1, SAT-2, SAT-3, and Asia-1. These serotypes show some regionality, and the O serotype is most common.