C型凝集素结构域家族9成员A抗体

C型凝集素结构域家族9成员A抗体
货号:bs-13620R
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概述

产品编号
bs-13620R
英文名称
CLEC9A Rabbit pAb
中文名称
C型凝集素结构域家族9成员A抗体
英文别名
9830005G06Rik; DNGR-1; CLC9A_MOUSE; Clec9a; Dendritic cell natural killer lectin group receptor 1; CD370; DNGR1; UNQ9341;
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human CLEC9A: 101-200/241
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
27 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料
The C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily consists of a variety of proteins that share a common protein fold and have diverse functions, including cell-cell signaling, cell adhesion, glycoprotein turnover and immune responses. CLEC-9A (C-type lectin domain family 9 member A), also known as DNGR1 (dendritic cell natural killer lectin group receptor 1), is a 241 amino acid single-pass type II membrane protein that contains one C-type lectin domain and belongs to the CTL/CTLD superfamily. Expressed in myeloid lineage cells, brain, spleen and thymus, CLEC-9A is a group V C-type lectin-like receptor (CTLR) that acts as an activation receptor. The gene encoding CLEC-9A maps to human chromosome 12p13.2 and mouse chromosome 6 F3.
C型凝集素结构域家族9成员A抗体C型凝集素结构域家族9成员A抗体

产品应用

应用已检合格种属预测种属推荐稀释比例
WBMouseHuman, Rat1:500-2000
IHC-PRatHuman, Mouse1:100-500
IHC-FRatHuman, Mouse1:100-500
IFRatHuman, Mouse1:100-500

交叉反应

交叉反应: Mouse, Rat (predicted: Human)

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靶标

基因名
CLEC9A
蛋白名
C-type lectin domain family 9 member A
亚细胞定位
Membrane.
组织特异性
In peripheral blood highly restricted on the surface of BDCA31(+) dendritic cells and on a small subset of CD14(+) and CD16(-) monocytes.
翻译后修饰
N-glycosylated.
相似性
Contains 1 C-type lectin domain.
功能
Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner.

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