The C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily consists of a variety of proteins that share a common protein fold and have diverse functions, including cell-cell signaling, cell adhesion, glycoprotein turnover and immune responses. CLEC-9A (C-type lectin domain family 9 member A), also known as DNGR1 (dendritic cell natural killer lectin group receptor 1), is a 241 amino acid single-pass type II membrane protein that contains one C-type lectin domain and belongs to the CTL/CTLD superfamily. Expressed in myeloid lineage cells, brain, spleen and thymus, CLEC-9A is a group V C-type lectin-like receptor (CTLR) that acts as an activation receptor. The gene encoding CLEC-9A maps to human chromosome 12p13.2 and mouse chromosome 6 F3.
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
WB
Mouse
Human, Rat
1:500-2000
IHC-P
Rat
Human, Mouse
1:100-500
IHC-F
Rat
Human, Mouse
1:100-500
IF
Rat
Human, Mouse
1:100-500
交叉反应
交叉反应: Mouse, Rat (predicted: Human)
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靶标
基因名
CLEC9A
蛋白名
C-type lectin domain family 9 member A
亚细胞定位
Membrane.
组织特异性
In peripheral blood highly restricted on the surface of BDCA31(+) dendritic cells and on a small subset of CD14(+) and CD16(-) monocytes.
翻译后修饰
N-glycosylated.
相似性
Contains 1 C-type lectin domain.
功能
Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner.