TAF1B Antibody Blocking Peptide (合成多肽) | Bioss

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货号：bs-12898P
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概述

产品编号
bs-12898P
英文名称
TAF1B Antibody Blocking Peptide
中文名称
TATA盒结合蛋白相关因子TAF1B封闭多肽
英文别名
MGC:9349; RAF1B; RAFI63; SL1; TAB1 B; TAF1B TATA box binding protein (TBP) associated factor, RNA polymerase I, B, 63kDa; TAFI63; TATA box binding protein associated factor 1B; TATA box binding protein associated factor RNA polymerase I subunit B.
纯化方法
HPLC
研究领域

Epigenetics and Nuclear Signaling > Transcription > Polymerase associated factors > Pol I Transcription

Epigenetics and Nuclear Signaling > Transcription > Polymerase associated factors > Pol II Transcription > TAFs

Epigenetics and Nuclear Signaling > Transcription > Preinitiation complex

活性
Not tested
保存条件
Shipped at 4℃. Stored at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接

Entrez Gene : 9014 Human

Omim : 604904 Human

SwissProt : Q53T94 Human

背景资料
Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes one of the SL1-specific TAFs. [provided by RefSeq, Jul 2008]

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靶标

基因名
TAF1B
蛋白名
TATA box-binding protein-associated factor RNA polymerase I subunit B
亚基
Interacts with FLNA (via N-terminus) (By similarity). Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. In the complex interacts directly with TBP, TAF1A and TAF1C. Interaction of the SL1/TIF-IB subunits with TBP excludes interaction of TBP with the transcription factor IID (TFIID) subunits. Interacts with TBP and RRN3.
亚细胞定位
Nuclear.
功能
Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during trancription initiation such as preinitiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3.

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