Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
WB
Mouse
1:500-2000
Flow-Cyt
Mouse
2ug/Test
交叉反应
交叉反应: Mouse
相关产品
暂无相关产品
靶标
基因名
PTGER4
蛋白名
Prostaglandin E2 receptor EP4 subtype
亚基
Interacts with FEM1A.
亚细胞定位
Cell membrane.
组织特异性
High in intestine and in peripheral blood mononuclear cells; low in lung, kidney, thymus, uterus, vasculature and brain. Not found in liver, heart, retina oe skeletal muscle.
翻译后修饰
Phosphorylation mediates agonist-mediated desensitization by promoting cytoplasmic retention.
相似性
Belongs to the G-protein coupled receptor 1 family.
功能
Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function.