Hemagglutinin (HA) is a class I viral fusion protein from Influenza virus. It is a major glycoprotein, comprising over 80% of the envelope proteins present in the virus particle. HA binds to sialic acid-containing receptors on the cell surface, bringing about the attachment of the virus particle to the cell, and is responsible for penetration of the virus into the cell cytoplasm by mediating the fusion of the membrane of the endocytosed virus particle with the endosomal membrane. The extent of infection into host organism is determined by HA. In natural infection, inactive HA is matured into HA1 and HA2 outside the cell by one or more trypsin-like, arginine-specific endoproteases secreted by the bronchial epithelial cells. The HA protein is a homotrimer of disulfide-linked HA1-HA2. It also plays a major role in the determination of host range restriction and virulence. Genetic variation of hemagglutinin and/or neuraminidase genes results in the emergence of new influenza strains.
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
ELISA
Influenza A virus H3N1
1:5000-10000
交叉反应
交叉反应: (predicted: Influenza A virus H3N1)
相关产品
暂无相关产品
靶标
基因名
HA
蛋白名
hemagglutinin
亚基
Homotrimer of disulfide-linked HA1-HA2.
亚细胞定位
Cell membrane; apical cell membrane; single-pass type I membrane protein.
相似性
Belongs to the influenza viruses hemagglutinin family.