ABCB6 Rabbit pAb (一抗) - IHC-P,IHC-F,IF | Bioss

2026-03-02~2026-04-30,KXJ26032026-03-02~2026-04-30,促销赠品
ABCB6 Rabbit pAb (一抗) - IHC-P,IHC-F,IF | Bioss
货号:bs-1224R
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概述

产品编号
bs-1224R
产品类型
宠物抗体、农牧业/家禽抗体
英文名称
ABCB6 Rabbit pAb
中文名称
ATP结合蛋白家族6抗体
英文别名
ABC; LAN; MTABC3; PRP; umat; 1200005B17Rik; ABCB6_HUMAN; ABCB6; ABC-type heme transporter ABCB6; Mitochondrial ABC transporter 3 (Mt-ABC transporter 3); P-glycoprotein-related protein; Ubiquitously-expressed mammalian ABC half transporter; ABCB6_MOUSE; ABCB6_RAT; Q9Z1S2_RAT;
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human ABCB6: 401-520/842
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
94 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍
ABCB6蛋白对于红细胞携带氧,肝细胞破坏毒素以及细胞从摄取营养物质后排放能量方面发挥重要的作用。
背景资料
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This half-transporter likely plays a role in mitochondrial function. Localized to 2q26, this gene is considered a candidate gene for lethal neonatal metabolic syndrome, a disorder of mitochondrial function.
ATP结合蛋白家族6抗体-bs-1224RATP结合蛋白家族6抗体-bs-1224RATP结合蛋白家族6抗体-bs-1224R

产品应用

应用已检合格种属预测种属推荐稀释比例
IHC-PRatHuman, Mouse, Pig, Cow, Dog, GuineaPig, Horse1:100-500
IHC-FRatHuman, Mouse, Pig, Cow, Dog, GuineaPig, Horse1:100-500
IFRatHuman, Mouse, Pig, Cow, Dog, GuineaPig, Horse1:100-500

交叉反应

交叉反应: Rat (predicted: Human, Mouse, Pig, Cow, Dog, GuineaPig, Horse)

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靶标

基因名
ABCB6
蛋白名
ATP-binding cassette sub-family B member 6, mitochondrial
亚基
Homodimer.
亚细胞定位
Cell membrane. Mitochondrion outer membrane; Multi-pass membrane protein. Endoplasmic reticulum. Golgi apparatus.
组织特异性
Widely expressed. High expression is detected in the retinal epithelium.
疾病
Microphthalmia, isolated, with coloboma, 7 (MCOPCB7) [MIM:614497]: A disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues. Ocular abnormalities like opacities of the cornea and lens, scaring of the retina and choroid, cataract and other abnormalities like cataract may also be present. Ocular colobomas are a set of malformations resulting from abnormal morphogenesis of the optic cup and stalk, and the fusion of the fetal fissure (optic fissure). Note=The disease is caused by mutations affecting the gene represented in this entry.
相似性
Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.
Contains 1 ABC transmembrane type-1 domain.
Contains 1 ABC transporter domain.
功能
Binds heme and porphyrins and functions in their ATP-dependent uptake into the mitochondria. Plays a crucial role in heme synthesis

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