EAAT2 Rabbit pAb (一抗) - WB,IHC-P,IHC-F,IF | Bioss

2026-05-01~2026-06-30,AB2605
EAAT2 Rabbit pAb (一抗) - WB,IHC-P,IHC-F,IF | Bioss
货号:bs-49183R
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概述

产品编号
bs-49183R
英文名称
EAAT2 Rabbit pAb
中文名称
胶质细胞谷氨酸运载蛋白2抗体
英文别名
DEE41; EAAT2; EIEE41; GLT-1; GLT1; HBGT; 1700091C19Rik; 2900019G14Rik; MGLT1; Glt; EAA2_HUMAN; SLC1A2; Glutamate/aspartate transporter II; Sodium-dependent glutamate/aspartate transporter 2; Solute carrier family 1 member 2; EAA2_MOUSE; EAA2_RAT; Sodium-dependent glutamate/aspartate transporter 2 (GLUT-R); solute carrier family 1 (glial high affinity glutamate transporter), member 2; glutamate transporter-1; Excitatory amino acid transporter 2; human brain glutamate transporter
抗体来源
Rabbit
免疫原
Recombinant mouse EAAT2 protein: 460-572/572
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
62 kDa
检测分子量
36 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料
This gene encodes a member of a family of solute transporter proteins. The membrane-bound protein is the principal transporter that clears the excitatory neurotransmitter glutamate from the extracellular space at synapses in the central nervous system. Glutamate clearance is necessary for proper synaptic activation and to prevent neuronal damage from excessive activation of glutamate receptors. Mutations in and decreased expression of this protein are associated with amyotrophic lateral sclerosis. Alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Sep 2010]
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产品应用

应用已检合格种属预测种属推荐稀释比例
WBMouseHuman, Rat1:500-2000
IHC-PHuman, Mouse, Rat1:100-500
IHC-FHuman, Mouse, Rat1:100-500
IFHuman, Mouse, Rat1:100-500

交叉反应

交叉反应: Human, Mouse, Rat

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靶标

基因名
SLC1A2
蛋白名
Excitatory amino acid transporter 2
亚基
Homotrimer. Interacts with AJUBA.
亚细胞定位
Membrane; Multi-pass membrane protein.
组织特异性
Brain
翻译后修饰
Glycosylated.
Palmitoylation at Cys-38 is not required for correct subcellular localization, but is important for glutamate uptake activity.
相似性
Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family. SLC1A2 subfamily.
功能
Transports L-glutamate and also L- and D-aspartate. Essential for terminating the postsynaptic action of glutamate by rapidly removing released glutamate from the synaptic cleft. Acts as a symport by cotransporting sodium.

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