SAA1 Rabbit pAb (一抗) | Bioss
货号：bs-19359R
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概述
产品编号
bs-19359R
英文名称
SAA1 Rabbit pAb
中文名称
血清淀粉样蛋白A抗体
英文别名
PIG4; SAA; SAA2; TP53I4; Saa-1; SAA1_HUMAN; SAA1; SAA1_MOUSE;
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human SAA1: 41-94/122
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
14 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
Cardiovascular > Lipids / Lipoproteins > Lipoproteins/Apolipoproteins > Apolipoproteins
Immunology > Innate Immunity > Complement > Regulatory
Immunology > Innate Immunity > Cytokines
Immunology > Innate Immunity > Macrophage / Inflamm.
Signal Transduction > Signaling Pathway > G Protein Signaling > GPCR
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
This gene encodes a member of the serum amyloid A family of apolipoproteins. The encoded protein is a major acute phase protein that is highly expressed in response to inflammation and tissue injury. This protein also plays an important role in HDL metabolism and cholesterol homeostasis. High levels of this protein are associated with chronic inflammatory diseases including atherosclerosis, rheumatoid arthritis, Alzheimer's disease and Crohn's disease. This protein may also be a potential biomarker for certain tumors. Alternate splicing results in multiple transcript variants that encode the same protein. A pseudogene of this gene is found on chromosome 11.[provided by RefSeq, Jun 2012]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| IHC-P | Human | 1:100-500 | |
| IHC-F | Human | 1:100-500 | |
| IF | Human | 1:100-500 |
交叉反应
交叉反应: Human
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靶标
基因名
SAA1
蛋白名
Serum amyloid A-1 protein
亚基
Homohexamer; dimer of trimers. Can form amyloid fibrils after partial proteolysis; the native, undenatured protein does not form amyloid fibrils (in vitro). Apolipoprotein of the HDL complex. Binds to heparin.
亚细胞定位
Secreted.
组织特异性
Expressed by the liver; secreted in plasma (at protein level).
翻译后修饰
This protein is the precursor of amyloid protein A, which is formed by the removal of approximately 24 residues from the C-terminal end.
疾病
Reactive, secondary amyloidosis is characterized by the extracellular accumulation in various tissues of the SAA1 protein. These deposits are highly insoluble and resistant to proteolysis; they disrupt tissue structure and compromise function.
Elevated serum SAA1 protein levels may be associated with lung cancer.
Elevated serum SAA1 protein levels may be associated with lung cancer.
功能
Major acute phase reactant. Apolipoprotein of the HDL complex.
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