免疫原
Human fibrinogen cleavage product D-Dimer
纯化方法
affinity purified by Protein A
储存液
potassium phosphate buffer and sodium chloride. No preservatives are added.
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍
CAS号：9001-32-5
分子量：
α-chain 63.5 kDa;
β-chain 56 kDa;
γ chain 47 kDa (about 4% carbohydrate content);
soluble dimer 340 kDa;
MDL：MFCD00131060
级别：BR
蛋白含量：Type I-S, 65-85% protein (≥75% of protein is clottable)
来源：牛
外观：白色粉末
用途：细胞培养，合适哺乳动物。
纤维蛋白原已应用于外科和大规模创伤患者的止血治疗研究。这些研究表明，与使用新鲜冷冻血浆相比，纤维蛋白原在止血方面可能更为优越。
背景资料
Fibrinogen is the main protein of blood coagulation system. It is a large protein and it consists of two identical subunits that contain three polypeptide chains: alpha, beta and gamma. All chains are connected with each other by a number of disulfide bonds. Fibrinopeptides A (1 to 16 amino acids) and B (1 to 17 amino acids) are released by thrombin from the N terminal parts of alpha and beta chains, respectively. In this way fibrinogen is converted into fibrin, which by means of polymerization forms a fibrin clot. Fibrinogen clotting underlies pathogenesis of MI, thromboembolism and thromboses of arteries and veins, since fibrin is the main substrate for thrombus formation. Fibrinogen activation is also involved in pathogenesis of inflammation, tumor growth and many other diseases. The normal fibrinogen concentration in plasma is about 3 mg/ml. The elevated level of fibrinogen in patient's blood is regarded as an independent risk factor for cardiovascular diseases. An increase in blood fibrinogen concentration was shown to be a strong predictor of coronary heart disease (Sonel A. et al, and Rapold H.J. et al). All these facts make fibrinogen an important parameter in the diagnosis of cardiovascular diseases.