PER1 Rabbit pAb (一抗) | Bioss
货号：bs-2350R
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概述
产品编号
bs-2350R
产品类型
宠物抗体、农牧业/家禽抗体
英文名称
PER1 Rabbit pAb
中文名称
节律抑制蛋白PER1抗体
英文别名
Rigui-like; PER; RIGUI; hPER; Hftm; m-rigui; mPer1; rper1; PER1_HUMAN; PER1; hPER1; Circadian clock protein PERIOD 1; Circadian pacemaker protein Rigui; KIAA0482; PER1_MOUSE; PER1_RAT; period circadian regulator 1; period (Drosophila) homolog 1; period homolog 1 (Drosophila); period circadian clock 1
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human PER1 protein: 751-850/1290
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
136 kDa
检测分子量
142 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
产品介绍
Per1蛋白的作用是机体生理节奏调节的核心基因，也是影响肿瘤发生发展的重要蛋白。调节机体生理节奏、调控细胞周期和促进DNA损伤修复等作用。Per1广泛参与了细胞的周期调控、DNA损伤修复、细胞凋亡和肿瘤细胞增殖等过程
背景资料
In mammals, several genes that encode members of the basic helix-loop helix (bHLH) PAS (PER-ARNT-SIM) transcription factor family have been shown to play a significant role in regulating circadian oscillations. Transactivation of CLOCK-induced genes is mediated via an E box enhancer (CACGTG) found upstream of target genes. CLOCK-ARNT 3 heterodimers bind to E box regulatory elements and stimulate gene transcription. CLOCK has been shown to transactivate the mammalian homolog of Drosophila PER. PER, in concert with the product of the mammalian timeless gene (TIM), negatively regulates its own transcription by blocking the activity of the CLOCK-BMAL 1 transactivation complex.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | Mouse, Rat, Rabbit, Pig, Cow, Dog, Horse | 1:500-2000 |
| IHC-P | Mouse | Human, Rat, Rabbit, Pig, Cow, Dog, Horse | 1:100-500 |
| IHC-F | Mouse | Human, Rat, Rabbit, Pig, Cow, Dog, Horse | 1:100-500 |
| IF | Mouse | Human, Rat, Rabbit, Pig, Cow, Dog, Horse | 1:100-500 |
交叉反应
交叉反应: Human, Mouse (predicted: Rat, Rabbit, Pig, Cow, Dog, Horse)
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靶标
基因名
PER1
蛋白名
Period circadian protein homolog 1
亚基
Component of the circadian core oscillator, which includes the CRY proteins, CLOCK or NPAS2, BMAL1 or BMAL2, CSNK1D and/or CSNK1E, TIMELESS, and the PER proteins. Interacts directly with TIMELESS, PER2, PER3 and, through a C-terminal domain, with CRY1 and CRY2. Interaction with CSNK1D or CSNK1E promotes nuclear location of PER proteins. Interacts with GPRASP1 (By similarity). Binding to CSNK1G2 triggers proteasomal degradation.
亚细胞定位
Nucleus (By similarity). Cytoplasm (By similarity). Note=Mainly nuclear. Nucleocytoplasmic shuttling is effected by interaction with other circadian core oscillator proteins and/or by phosphorylation. Retention of PER1 in the cytoplasm occurs through PER1-PER2 heterodimer formation or by interaction with CSNK1E and/or phosphorylation which appears to mask the PER1 nuclear localization signal. Also translocated to the nucleus by CRY1 or CRY2 (By similarity).
组织特异性
Widely expressed. Found in heart, brain, placenta, lung, liver, skeletal muscle, pancreas, kidney, spleen, thymus, prostate, testis, ovary and small intestine. Highest level in skeletal muscle. Low level in kidney.
翻译后修饰
Phosphorylated on serine residues by CSNK1E. Also can be phosphorylated by the delta isoform. Phosphorylation by CSNK1 retains PER1 in the cytoplasm and leads to its ubiquitination and subsequent degradation.
Ubiquitinated (By similarity).
Ubiquitinated (By similarity).
相似性
Contains 1 PAC (PAS-associated C-terminal) domain.
Contains 2 PAS (PER-ARNT-SIM) domains.
Contains 2 PAS (PER-ARNT-SIM) domains.
功能
Component of the circadian clock mechanism which is essential for generating circadian rhythms. Negative element in the circadian transcriptional loop. Influences clock function by interacting with other circadian regulatory proteins and transporting them to the nucleus. Negatively regulates CLOCK|NPAS2-BMAL1|BMAL2-induced transactivation. Can bind heme (By similarity).
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