LATS2 Rabbit pAb (一抗) | Bioss
概述
This gene encodes a serine/threonine protein kinase belonging to the LATS tumor suppressor family. The protein localizes to centrosomes during interphase, and early and late metaphase. It interacts with the centrosomal proteins aurora-A and ajuba and is required for accumulation of gamma-tubulin and spindle formation at the onset of mitosis. It also interacts with a negative regulator of p53 and may function in a positive feedback loop with p53 that responds to cytoskeleton damage. Additionally, it can function as a co-repressor of androgen-responsive gene expression. [provided by RefSeq, Jul 2008]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human, Mouse, Rat | Rabbit, Cow, Chicken, Dog, Horse | 1:500-2000 |
| IHC-P | Human, Mouse, Rat | Rabbit, Cow, Chicken, Dog, Horse | 1:100-500 |
| IHC-F | Human, Mouse, Rat | Rabbit, Cow, Chicken, Dog, Horse | 1:100-500 |
| IF | Human, Mouse, Rat | Rabbit, Cow, Chicken, Dog, Horse | 1:100-500 |
交叉反应
交叉反应: Human, Mouse, Rat (predicted: Rabbit, Cow, Chicken, Dog, Horse)
相关产品
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靶标
Expressed at high levels in heart and skeletal muscle and at lower levels in all other tissues examined.
Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis (PubMed:18158288, PubMed:26437443, PubMed:26598551, PubMed:34404733).
The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ (PubMed:26437443, PubMed:26598551, PubMed:34404733).
Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration (PubMed:26598551, PubMed:34404733).
Also phosphorylates YAP1 in response to cell contact inhibition-driven WWP1 ubiquitination of AMOTL2, which results in LATS2 activation (PubMed:34404733).
Acts as a tumor suppressor which plays a critical role in centrosome duplication, maintenance of mitotic fidelity and genomic stability (PubMed:10871863).
Negatively regulates G1/S transition by down-regulating cyclin E/CDK2 kinase activity (PubMed:12853976).
Negative regulator of the androgen receptor (PubMed:15131260).
Phosphorylates SNAI1 in the nucleus leading to its nuclear retention and stabilization, which enhances its epithelial-mesenchymal transition and tumor cell invasion/migration activities (PubMed:21952048).
This tumor-promoting activity is independent of its effects upon YAP1 or WWTR1/TAZ (PubMed:21952048).
Acts as an activator of the NLRP3 inflammasome by mediating phosphorylation of 'Ser-265' of NLRP3 following NLRP3 palmitoylation, promoting NLRP3 activation by NEK7 (PubMed:39173637).