E2EPF Rabbit pAb (一抗) | Bioss
货号：bs-2305R
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概述
产品编号
bs-2305R
产品类型
宠物抗体、农牧业/家禽抗体
英文名称
E2EPF Rabbit pAb
中文名称
泛素交联酶抗体
英文别名
E2-EPF; E2EPF; EPF5; 0910001J09Rik; 6720465F12Rik; RGD1564746; UBE2S_BOVIN; UBE2S; E2 ubiquitin-conjugating enzyme S; Ubiquitin carrier protein S; Ubiquitin-protein ligase S; 2.3.2.23; UBE2S_HUMAN; Ubiquitin-conjugating enzyme E2-24 kDa; Ubiquitin-conjugating enzyme E2-EPF5; UBE2S_MOUSE; UBE2S_RAT;
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human E2EPF: LL(p-T)EI
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
24 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
This gene encodes a member of the ubiquitin-conjugating enzyme family. The encoded protein is able to form a thiol ester linkage with ubiquitin in a ubiquitin activating enzyme-dependent manner, a characteristic property of ubiquitin carrier proteins. [provided by RefSeq, Jul 2008]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| IHC-P | Rat | Human, Mouse, Rabbit, Pig, Cow, Dog, Horse | 1:100-500 |
| IHC-F | Rat | Human, Mouse, Rabbit, Pig, Cow, Dog, Horse | 1:100-500 |
| IF | Rat | Human, Mouse, Rabbit, Pig, Cow, Dog, Horse | 1:100-500 |
交叉反应
交叉反应: Rat (predicted: Human, Mouse, Rabbit, Pig, Cow, Dog, Horse)
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靶标
基因名
UBE2S
蛋白名
Ubiquitin-conjugating enzyme E2 S
亚基
Component of the APC/C complex. Interacts with CDC20, FZR1/CDH1 and VHL.
翻译后修饰
Autoubiquitinated by the APC/C complex during G1, leading to its degradation by the proteasome.
相似性
Belongs to the ubiquitin-conjugating enzyme family.
功能
Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. Catalyzes 'Lys-11'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by specifically elongating 'Lys-11'-linked polyubiquitin chains initiated by the E2 enzyme UBE2C/UBCH10 on APC/C substrates, enhancing the degradation of APC/C substrates by the proteasome and promoting mitotic exit. Also acts by elongating ubiquitin chains initiated by the E2 enzyme UBE2D1/UBCH5 in vitro; it is however unclear whether UBE2D1/UBCH5 acts as a E2 enzyme for the APC/C in vivo. Also involved in ubiquitination and subsequent degradation of VHL, resulting in an accumulation of HIF1A. In vitro able to promote polyubiquitination using all 7 ubiquitin Lys residues, except 'Lys-48'-linked polyubiquitination.
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