This gene encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the pentapeptide opioids Met-enkephalin and Leu-enkephalin, which are stored in synaptic vesicles, then released into the synapse where they bind to mu- and delta-opioid receptors to modulate the perception of pain. Other non-opioid cleavage products may function in distinct biological activities. [provided by RefSeq, Jul 2015]
产品应用
应用
已检合格种属
预测种属
推荐稀释比例
Flow-Cyt
Human
Mouse, Rat
2ug/Test
交叉反应
交叉反应: Human (predicted: Mouse, Rat)
相关产品
暂无相关产品
靶标
基因名
PENK
蛋白名
Proenkephalin-A
亚细胞定位
Secreted.
翻译后修饰
The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.
相似性
Belongs to the opioid neuropeptide precursor family.
功能
Met- and Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. PENK(114-133) and PENK(237-258) increase glutamate release in the striatum. PENK(114-133) decreases GABA concentration in the striatum.