SAV1 Rabbit pAb (一抗) | Bioss
货号：bs-17245R
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概述
产品编号
bs-17245R
产品类型
宠物抗体、农牧业/家禽抗体
英文名称
SAV1 Rabbit pAb
中文名称
SAV1蛋白抗体
英文别名
SAV; WW45; WWP4; 1700040G09Rik; Salv; Wwp3; SAV1_HUMAN; SAV1; 45 kDa WW domain protein (hWW45); SAV1_MOUSE; 45 kDa WW domain protein (mWW45); SAV1_RAT; 45 kDa WW domain protein (rWW45); salvador family WW domain containing protein 1; salvador homolog 1 (Drosophila); WW domain-containing adaptor 45
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human SAV1: 1-100/383
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
45 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
WW domain-containing proteins are found in all eukaryotes and play an important role in the regulation of a wide variety of cellular functions such as protein degradation, transcription, and RNA splicing. This gene encodes a protein with two WW domains, a SARAH domain, and a coiled-coil region and is ubiquitously expressed in adult tissues. This protein binds to MST1 (mammalian sterile 20-like kinase 1) and promotes MST1-induced apoptosis. It has also been shown to bind to HAX1 (hematopoietic cell-specific protein 1 (HS1)-associated protein X-1) and to attenuate the anti-apoptotic effects of HAX1. Studies in human and mouse suggest this gene acts as a tumor suppressor. [provided by RefSeq, Aug 2012]
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| IHC-P | Rat | Human, Mouse, Rabbit, Pig, Sheep, Cow, Dog, Horse | 1:100-500 |
| IHC-F | Rat | Human, Mouse, Rabbit, Pig, Sheep, Cow, Dog, Horse | 1:100-500 |
| IF | Rat | Human, Mouse, Rabbit, Pig, Sheep, Cow, Dog, Horse | 1:100-500 |
交叉反应
交叉反应: Rat (predicted: Human, Mouse, Rabbit, Pig, Sheep, Cow, Dog, Horse)
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靶标
基因名
SAV1
蛋白名
Protein salvador homolog 1
亚细胞定位
Nucleus. Cytoplasm.
组织特异性
Ubiquitously expressed in adult tissues with highest expression in the pancreas, aorta and interventricular septum and lowest expression in skeletal muscle. Expression was higher in fetal than in the adult heart. Expressed in various cell lines.
翻译后修饰
Phosphorylated by STK3 and STK4. Phosphorylation is not required for SAV1 stability and may increase the number of protein binding sites on the scaffold molecule.
相似性
Contains 1 SARAH domain.
Contains 2 WW domains.
Contains 2 WW domains.
功能
Regulator of MST1/MST2 in the Hippo signaling pathway which plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein MST1/MST2, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1/2 inhibits its translocation into the nucleus to regulate cellular genes important for cell proliferation, cell death, and cell migration. SAV1 is required for MST1/MST2 activation and promotes cell-cycle exit and terminal differentiation in developing epithelial tissues.
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