IFNGR2 Rabbit pAb (一抗) | Bioss
货号：bs-2710R
产品详情
相关标记
相关产品
相关文献
常见问题
概述
产品编号
bs-2710R
产品类型
宠物抗体、农牧业/家禽抗体
英文名称
IFNGR2 Rabbit pAb
中文名称
干扰素-gamma受体2/干扰素-gamma受体β/IFN-γRβ抗体
英文别名
AF-1; IFGR2; IFNGT1; IMD28; Ifgt; INGR2_HUMAN; IFNGR2; IFN-gamma receptor 2; IFN-gamma-R2; Interferon gamma receptor accessory factor 1 (AF-1); Interferon gamma receptor beta-chain (IFN-gamma-R-beta); Interferon gamma transducer 1;
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from human IFNGR2: 241-337/337 <Extracellular>
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
36 kDa
检测分子量
35 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
IFN gamma receptor beta is part of the receptor for interferon gamma. This class II cytokine receptor pairs with CDw119 to form the IFN gamma receptor and is an integral part of the IFN gamma signal transduction pathway. CDw119 serves as the IFN gamma binding chain and associates with the IFN gamma beta chain which is required for receptor signaling. The extracellular portion of both the IFN gamma receptor alpha and beta chains must be species matched. The IFN gamma receptor beta chain is expressed on T and B cells, NK cells, monocytes/ macrophages, and fibroblasts. Binding of IFN gamma induces receptor dimerization, internalization, Jak1 and Jak2 protein kinase activation and, ultimately, STAT1 activation. It is also likely to interact with GAF. IFN gamma initiates and regulates a variety of immune responses and is required for signal transduction. Contains 2 fibronectin type III domains. Defects in IFN gamma Receptor beta are a cause of mendelian susceptibility to mycobacterial disease (MSMD), a rare condition that confers predisposition to illness caused by several mycobacteria strains.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| WB | Human | Mouse, Rat, Rabbit, Cow, Dog | 1:500-2000 |
| IHC-P | Human | Mouse, Rat, Rabbit, Cow, Dog | 1:100-500 |
| IHC-F | Human | Mouse, Rat, Rabbit, Cow, Dog | 1:100-500 |
| IF | Human | Mouse, Rat, Rabbit, Cow, Dog | 1:100-500 |
交叉反应
交叉反应: Human (predicted: Mouse, Rat, Rabbit, Cow, Dog)
相关产品
暂无相关产品
靶标
基因名
IFNGR2
蛋白名
Interferon gamma receptor 2
亚细胞定位
Membrane; Single-pass type I membrane protein.
疾病
Defects in IFNGR2 are a cause of mendelian susceptibility to mycobacterial disease (MSMD) [MIM:209950]; also known as familial disseminated atypical mycobacterial infection. This rare condition confers predisposition to illness caused by moderately virulent mycobacterial species, such as Bacillus Calmette-Guerin (BCG) vaccine and environmental non-tuberculous mycobacteria, and by the more virulent Mycobacterium tuberculosis. Other microorganisms rarely cause severe clinical disease in individuals with susceptibility to mycobacterial infections, with the exception of Salmonella which infects less than 50% of these individuals. The pathogenic mechanism underlying MSMD is the impairment of interferon-gamma mediated immunity, whose severity determines the clinical outcome. Some patients die of overwhelming mycobacterial disease with lepromatous-like lesions in early childhood, whereas others develop, later in life, disseminated but curable infections with tuberculoid granulomas. MSMD is a genetically heterogeneous disease with autosomal recessive, autosomal dominant or X-linked inheritance.
相似性
Belongs to the type II cytokine receptor family.
Contains 2 fibronectin type-III domains.
Contains 2 fibronectin type-III domains.
功能
Part of the receptor for interferon gamma. Required for signal transduction. This accessory factor is an integral part of the IFN-gamma signal transduction pathway and is likely to interact with GAF, JAK1, and/or JAK2.
同靶标产品
相关文献
提示: 发表研究结果有使用 bs-2710R 时请让我们知道，以便我们可以引用参考文章。作为回馈，资料提供者将获得我们送上的小礼品。
具体参考文献:bs-2710R 被引用于3文献中