白细胞介素28受体α抗体

白细胞介素28受体α抗体
货号:bs-20896R
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概述

产品编号
bs-20896R
英文名称
IL28 Receptor alpha Rabbit pAb
中文名称
白细胞介素28受体α抗体
英文别名
CRF2/12; IFNLR; IL-28R1; IL28RA; LICR2; CRF2-12; RGD1562689; INLR1_HUMAN; IFNLR1; IFN-lambda receptor 1; IFN-lambda-R1; Cytokine receptor class-II member 12; Cytokine receptor family 2 member 12 (CRF2-12); Interleukin-28 receptor subunit alpha (IL-28 receptor subunit alpha | IL-28R-alpha | IL-28RA); Likely interleukin or cytokine receptor 2 (LICR2); INLR1_MOUSE; IFN-lambda R1;
抗体来源
Rabbit
免疫原
KLH conjugated synthetic peptide derived from mouse IL28 Receptor alpha: 21-120/520 <Extracellular>
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
56 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
背景资料
The protein encoded by this gene belongs to the class II cytokine receptor family. This protein forms a receptor complex with interleukine 10 receptor, beta (IL10RB). The receptor complex has been shown to interact with three closely related cytokines, including interleukin 28A (IL28A), interleukin 28B (IL28B), and interleukin 29 (IL29). The expression of all three cytokines can be induced by viral infection. The cells overexpressing this protein have been found to have enhanced responses to IL28A and IL29, but decreased response to IL28B. Three alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]
白细胞介素28受体α抗体白细胞介素28受体α抗体

产品应用

应用已检合格种属预测种属推荐稀释比例
WBHuman, Mouse1:500-2000

交叉反应

交叉反应: Human, Mouse

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靶标

基因名
IFNLR1
蛋白名
Interferon lambda receptor 1
亚基
Heterodimer with IL10RB.
亚细胞定位
Membrane; Single-pass type I membrane protein
组织特异性
Widely expressed.
相似性
Belongs to the type II cytokine receptor family.
Contains 1 fibronectin type-III domain.
功能
IL28RA is a class II cytokine receptor that interacts with IL10RB to bind IL28A, IL28B, and IL29, which are related to type I interferons. These ligands play a critical role in response to microbial challenge and activate the JAK/STAT signaling system. It heterodimers with IL10RB. There are 4 isoforms as result of alternative splicing. It is widely expressed. IL28RA belongs to the type II cytokine receptor family, and contains 1 fibronectin type III domain.

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