半胱胺酸蛋白酶蛋白-3抗体

bs-0081R

Caspase-3 Rabbit pAb

半胱胺酸蛋白酶蛋白-3抗体

CPP32; CPP32B; SCA-1; A830040C14Rik; AC-3; CASP-3; CC3; CPP-32; Caspase-3; Lice; Yama; mldy; CPP32-beta; CASP3_HUMAN; CASP3; Apopain; Cysteine protease CPP32 (CPP-32); Protein Yama; SREBP cleavage activity 1 (SCA-1); 3.4.22.56; CASP3_MOUSE; CASP3_PIG; CASP3_RABIT; Cysteine protease CPP32; CASP3_RAT; IRP;

Rabbit

KLH conjugated synthetic peptide derived from human caspase-3 p17 subunit: 80-175/277

IgG

Liquid

affinity purified by Protein A

Polyclonal

17/32 kDa

1mg/ml

0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

正常情况下caspase-3以无活性酶原形式存在于细胞浆中。当 caspase-3被上游caspases激活生成活化的caspase-3 p17和p12亚基，对细胞凋亡的发生和调制发挥重要作用。

The caspase family of cysteine proteases play a key role in apoptosis. Caspase 3 is the most extensively studied apoptotic protein among caspase family members. Caspase 3 is synthesized as inactive pro enzyme that is processed in cells undergoing apoptosis by self proteolysis and/or cleavage by other upstream proteases (e.g. Caspases 8, 9 and 10). The processed form of Caspase 3 consists of large (17kDa) and small (12kDa) subunits which associate to form an active enzyme. Caspase 3 is cleaved at Asp28 Ser29 and Asp175 Ser176. The active Caspase 3 proteolytically cleaves and activates other caspases (e.g. Caspases 6, 7 and 9), as well as relevant targets in the cells (e.g. PARP and DFF). Alternative splicing of this gene results in two transcript variants which encode the same protein. In immunohistochemical studies Caspase 3 expression has been shown to be widespread but not present in all cell types (e.g. commonly reported in epithelial cells of skin, renal proximal tubules and collecting ducts). Differences in the level of Caspase 3 have been reported in cells of short lived nature (eg germinal centre B cells) and those that are long lived (eg mantle zone B cells). Caspase 3 is the predominant caspase involved in the cleavage of amyloid beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease.