phospho-14-3-3 epsilon (Thr232) Rabbit pAb (一抗) | Bioss
货号：bs-5590R
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概述
产品编号
bs-5590R
产品类型
磷酸化抗体、农牧业/家禽抗体
英文名称
phospho-14-3-3 epsilon (Thr232) Rabbit pAb
中文名称
磷酸化14-3-3E蛋白抗体
英文别名
14-3-3E; HEL2; KCIP-1; MDCR; MDS; 1433E_BOVIN; YWHAE; 1433E_HUMAN; 1433E_MOUSE; 1433E_RAT; Mitochondrial import stimulation factor L subunit (MSF L); tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, epsilon polypeptide; 14-3-3 epsilon; YWHAE | 14-3-3 epsilon (phospho-T232); p-14-3-3 epsilon; phospho-14-3-3 epsilon; p-YWHAE; YWHAE | 14-3-3 epsilon (phospho-Thr232)
抗体来源
Rabbit
免疫原
KLH conjugated Synthesised phosphopeptide derived from human 14-3-3E around the phosphorylation site of Thr232: LW(p-T)SD
亚型
IgG
性状
Liquid
纯化方法
affinity purified by Protein A
克隆类型
Polyclonal
理论分子量
29 kDa
浓度
1mg/ml
储存液
0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
研究领域
SWISS
Gene ID
保存条件
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
注意事项
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
数据库链接
背景资料
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathway. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
产品应用
| 应用 | 已检合格种属 | 预测种属 | 推荐稀释比例 |
|---|---|---|---|
| Flow-Cyt | Human | Mouse, Rat, Sheep, Cow | 1μg/Test |
交叉反应
交叉反应: Human (predicted: Mouse, Rat, Sheep, Cow)
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暂无相关产品
靶标
基因名
YWHAE
蛋白名
14-3-3 protein epsilon
亚基
Homodimer. Heterodimerizes with YWHAZ. Interacts with NDEL1, RGNEF and TIAM2. Interacts with HCV core protein. Interacts with ABL1 (phosphorylated form); the interaction retains it in the cytoplasm. Weakly interacts with CDKN1B. Interacts with GAB2. Interacts with phosphorylated GRB10. Interacts with PKA-phosphorylated AANAT. Interacts with the phosphorylated (by AKT1) form of SRPK2.
亚细胞定位
Cytoplasm. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.
翻译后修饰
The delta, brain-specific form differs from the zeta form in being phosphorylated. Phosphorylation on Ser-184 by MAPK8; promotes dissociation of BAX and translocation of BAX to mitochondria. Phosphorylation on Ser-58 by PKA; disrupts homodimerization and heterodimerization with YHAE and TP53. This phosphorylation appears to be activated by sphingosine. Phosphorylation on Thr-232; inhibits binding of RAF1.
相似性
Belongs to the 14-3-3 family.
功能
Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner.
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